L
Leonora Balaj
Researcher at Harvard University
Publications - 80
Citations - 16354
Leonora Balaj is an academic researcher from Harvard University. The author has contributed to research in topics: Microvesicles & Liquid biopsy. The author has an hindex of 36, co-authored 71 publications receiving 10867 citations. Previous affiliations of Leonora Balaj include VU University Medical Center & Poznan University of Medical Sciences.
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Journal ArticleDOI
Liquid biopsy for brain tumors
TL;DR: There is a future potential to precisely diagnose and monitor treatment response with liquid biopsies in personalized medicine, as the technologies used to analyze these biomarkers continue to evolve.
Journal ArticleDOI
Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson's Disease, Glioma, and Schwannoma.
Justin Hall,Justin Hall,Shilpa Prabhakar,Leonora Balaj,Charles P. Lai,Charles P. Lai,Richard A. Cerione,Xandra O. Breakefield +7 more
TL;DR: Therapeutic proteins can be loaded into vesicles by overexpression in the donor cell, with oligomerization and membrane sequences increasing their loading, and this therapeutic delivery strategy is novel and being explored for a number of diseases.
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Extracellular Mitochondria in Cerebrospinal Fluid and Neurological Recovery After Subarachnoid Hemorrhage
Sherry H.-Y. Chou,Jing Lan,Elga Esposito,MingMing Ning,Leonora Balaj,Xunming Ji,Eng H. Lo,Kazuhide Hayakawa +7 more
TL;DR: It is suggested that extracellular mitochondria may provide a biomarker-like glimpse into brain integrity and recovery after injury and be correlated with good clinical recovery at 3 months after SAH onset.
Journal ArticleDOI
Extracellular Vesicles in Glioblastoma Tumor Microenvironment.
Anuroop Yekula,Anudeep Yekula,Koushik Muralidharan,Keiko Kang,Keiko Kang,Bob S. Carter,Leonora Balaj +6 more
TL;DR: Recent literature in the context of GBM TME is reviewed and the means by which EVs modulate tumor proliferation, reprogram metabolic activity, induce angiogenesis, escape immune surveillance, acquire drug resistance and undergo invasion are reviewed.
Journal ArticleDOI
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma.
Jongmin Park,Jongmin Park,Jun Seok Park,Jun Seok Park,Chen Han Huang,Chen Han Huang,Ala Jo,Kaitlyn Cook,Rui Wang,Hsing Ying Lin,Jan Van Deun,Huiyan Li,Jouha Min,Lan Wang,Ghilsuk Yoon,Bob S. Carter,Leonora Balaj,Gyu-Seog Choi,Cesar M. Castro,Ralph Weissleder,Hakho Lee +20 more
TL;DR: In this article, a 96-well assay that integrates the enrichment of EVs by antibody-coated magnetic beads and the electrochemical detection, in less than one hour of total assay time, of EV-bound proteins after enzymatic amplification was presented.