L
Li Ye
Researcher at Stanford University
Publications - 39
Citations - 11528
Li Ye is an academic researcher from Stanford University. The author has contributed to research in topics: Adipose tissue & Thermogenesis. The author has an hindex of 22, co-authored 38 publications receiving 9685 citations. Previous affiliations of Li Ye include Howard Hughes Medical Institute & Harvard University.
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Journal ArticleDOI
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Pontus Boström,Jun Wu,Mark P. Jedrychowski,Anisha Korde,Li Ye,James C. Lo,Kyle A. Rasbach,Elisabeth A. Boström,Jang Hyun Choi,Jonathan Z. Long,Shingo Kajimura,Maria Cristina Zingaretti,Birgitte F. Vind,Hua Tu,Saverio Cinti,Kurt Højlund,Steven P. Gygi,Bruce M. Spiegelman +17 more
TL;DR: This article showed that PGC1α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin.
Journal ArticleDOI
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Jun Wu,Pontus Boström,Lauren M. Sparks,Li Ye,Jang Hyun Choi,An Hoa Giang,Melin J. Khandekar,Kirsi A. Virtanen,Pirjo Nuutila,Gert Schaart,Kexin Huang,Hua Tu,Wouter D. van Marken Lichtenbelt,Joris Hoeks,Sven Enerbäck,Patrick Schrauwen,Bruce M. Spiegelman +16 more
TL;DR: Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin, providing evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes.
Journal ArticleDOI
Advanced CLARITY for rapid and high-resolution imaging of intact tissues
TL;DR: Protocols spanning multiple dimensions of the CLARITY workflow are described, ranging from simple, reliable and efficient lipid removal without electrophoretic instrumentation to optimized objectives and integration with light-sheet optics (CLARITY-optimized light- sheet microscopy (COLM)) for accelerating data collection from clarified samples by several orders of magnitude while maintaining or increasing quality and resolution.
Journal ArticleDOI
Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch
Paul Cohen,Julia D. Levy,Yingying Zhang,Andrea Frontini,Dmitriy Kolodin,Katrin J. Svensson,James C. Lo,James C. Lo,Xing Zeng,Li Ye,Melin J. Khandekar,Jun Wu,Subhadra C. Gunawardana,Alexander S. Banks,Joao Paulo Camporez,Michael J. Jurczak,Shingo Kajimura,David W. Piston,Diane Mathis,Saverio Cinti,Gerald I. Shulman,Patrick Seale,Bruce M. Spiegelman +22 more
TL;DR: It is shown that adipocyte-specific deletion of the coregulatory protein PRDM16 caused minimal effects on classical brown fat but markedly inhibited beige adipocyte function in subcutaneous fat following cold exposure or β3-agonist treatment, indicating that PRDM 16 and beige fat cells are required for the "browning" of white fat and the healthful effects of sub cutaneous adipose tissue.
Journal ArticleDOI
Transcriptional control of preadipocyte determination by Zfp423
Rana K. Gupta,Zoltan Arany,Patrick Seale,Rina J. Mepani,Li Ye,Heather M. Conroe,Yang A. Roby,Heather Kulaga,Randall R. Reed,Bruce M. Spiegelman +9 more
TL;DR: Using a new method for the quantitative analysis of transcriptional components, the zinc-finger protein Zfp423 is identified as a factor enriched in preadipose versus non-preadipose fibroblasts and regulates Pparg expression through amplification of the BMP signalling pathway.