L
Ligong Liu
Researcher at University of Queensland
Publications - 112
Citations - 6825
Ligong Liu is an academic researcher from University of Queensland. The author has contributed to research in topics: Mucosal associated invariant T cell & Antigen. The author has an hindex of 35, co-authored 107 publications receiving 5562 citations. Previous affiliations of Ligong Liu include Australian Research Council & Deakin University.
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Journal ArticleDOI
MR1 presents microbial vitamin B metabolites to MAIT cells
Lars Kjer-Nielsen,Onisha Patel,Alexandra J. Corbett,Jérôme Le Nours,Jérôme Le Nours,Bronwyn S. Meehan,Ligong Liu,Mugdha Bhati,Zhenjun Chen,Lyudmila Kostenko,Rangsima Reantragoon,Nicholas A. Williamson,Anthony W. Purcell,Anthony W. Purcell,Nadine L. Dudek,Nadine L. Dudek,Malcolm J. McConville,Richard A. J. O'Hair,George N. Khairallah,Dale I. Godfrey,David P. Fairlie,Jamie Rossjohn,Jamie Rossjohn,Jamie Rossjohn,James McCluskey +24 more
TL;DR: It is shown that metabolites of vitamin B represent a class of antigen that are presented by MR1 for MAIT-cell immunosurveillance, and data suggest that MAIT cells use these metabolites to detect microbial infection.
Journal ArticleDOI
T-cell activation by transitory neo-antigens derived from distinct microbial pathways
Alexandra J. Corbett,Sidonia B G Eckle,Richard W Birkinshaw,Ligong Liu,Onisha Patel,Jennifer Mahony,Zhenjun Chen,Rangsima Reantragoon,Bronwyn S. Meehan,Hanwei Cao,Nicholas A. Williamson,Richard A. Strugnell,Douwe van Sinderen,Jeffrey Y. W. Mak,David P. Fairlie,Lars Kjer-Nielsen,Jamie Rossjohn,James McCluskey +17 more
TL;DR: It is shown that MAIT-cell activation requires key genes encoding enzymes that form 5-amino-6-d-ribitylaminouracil (5-A-RU), an early intermediate in bacterial riboflavin synthesis, and MR1 is able to capture, stabilize and present chemically unstable pyrimidine intermediates, which otherwise convert to lumazines, as potent antigens to MAIT cells.
Journal ArticleDOI
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
Rangsima Reantragoon,Alexandra J. Corbett,Isaac G. Sakala,Nicholas A Gherardin,Nicholas A Gherardin,John B. Furness,Zhenjun Chen,Sidonia B G Eckle,Adam P Uldrich,Richard W Birkinshaw,Onisha Patel,Lyudmila Kostenko,Bronwyn S. Meehan,Katherine Kedzierska,Ligong Liu,David P. Fairlie,Ted H. Hansen,Dale I. Godfrey,Jamie Rossjohn,Jamie Rossjohn,James McCluskey,Lars Kjer-Nielsen +21 more
TL;DR: Generation of antigen-loaded MR1 tetramers that specifically stain MAIT cells identifies heterogeneity in phenotypes and TCR repertoires in humans and mice.
Journal ArticleDOI
Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant t cells using MR1 tetramers
Azad Rahimpour,Hui-Fern Koay,Anselm Enders,Rhiannon Clanchy,Sidonia B G Eckle,Bronwyn S. Meehan,Zhenjun Chen,Belinda Whittle,Ligong Liu,David P. Fairlie,Christopher C. Goodnow,James McCluskey,Jamie Rossjohn,Jamie Rossjohn,Adam P Uldrich,Daniel G. Pellicci,Dale I. Godfrey +16 more
TL;DR: This work uses MR1 tetramers to characterize the heterogeneous population of mouse MAIT cells and finds a close resemblance to their human counterparts, which will provide the foundation for further investigation ofMAIT cells in health and disease.
Journal ArticleDOI
A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage
Hui-Fern Koay,Nicholas A Gherardin,Nicholas A Gherardin,Anselm Enders,Liyen Loh,Laura K. Mackay,Laura K. Mackay,Catarina F. Almeida,Brendan E. Russ,Claudia A. Nold-Petry,Claudia A. Nold-Petry,Marcel F. Nold,Marcel F. Nold,Sammy Bedoui,Zhenjun Chen,Alexandra J. Corbett,Sidonia B G Eckle,Bronwyn S. Meehan,Yves d'Udekem,Igor E. Konstantinov,Martha Lappas,Ligong Liu,Christopher C. Goodnow,David P. Fairlie,Jamie Rossjohn,Jamie Rossjohn,Jamie Rossjohn,Mark M.W. Chong,Katherine Kedzierska,Stuart P. Berzins,Stuart P. Berzins,Gabrielle T. Belz,Gabrielle T. Belz,James McCluskey,Adam P Uldrich,Adam P Uldrich,Dale I. Godfrey,Dale I. Godfrey,Daniel G. Pellicci,Daniel G. Pellicci +39 more
TL;DR: Stage 3 MAIT cell populations were expanded in mice deficient in the antigen-presenting molecule CD1d, suggestive of a niche shared by MAIT cells and natural killer T cells (NKT cells).