Liisa Koski

TL;DR: This work used RNA-mediated interference to target 98% of all genes predicted in the C. elegans genome in combination with differential interference contrast time-lapse microscopy and developed a phenotypic profiling system, which shows high correlation with cellular processes and biochemical pathways, thus enabling to predict new functions for previously uncharacterized genes.

TL;DR: The analysis of the genomes of a crenarcheaota species Aeropyrum pernix, an organism with few close relatives fully sequenced, and Escherichia coli, an organisms whose closest relative, Salmonella typhimurium, is completely sequenced are chosen.

TL;DR: This work presents AutoFACT, a fully automated and customizable annotation tool that assigns biologically informative functions to a sequence and determines the most informative functional description by combining multiple BLAST reports from several user-selected databases.

TL;DR: A phylogenetic approach was employed to confirm selected examples of horizontal transmission among the novel groups of genes, and determined that a number of genes previously classified as horizontally transferred based on base composition and codon bias were native, and genes previously classification as native appeared to be horizontally transferred.

TL;DR: The TBestDB database is opened to the research community for free processing, annotation, interspecies comparisons and GenBank submission of EST data generated in individual laboratories.