L
Linda Spatz
Researcher at City College of New York
Publications - 15
Citations - 984
Linda Spatz is an academic researcher from City College of New York. The author has contributed to research in topics: Antibody & Anti-dsDNA antibodies. The author has an hindex of 10, co-authored 15 publications receiving 905 citations. Previous affiliations of Linda Spatz include Rockefeller University & City University of New York.
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Journal ArticleDOI
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
Florian Klein,Ariel Halper-Stromberg,Joshua A. Horwitz,Henning Gruell,Henning Gruell,Johannes F. Scheid,Johannes F. Scheid,Stylianos Bournazos,Hugo Mouquet,Linda Spatz,Linda Spatz,Ron Diskin,Alexander Abadir,Trinity Zang,Marcus Dorner,Eva Billerbeck,Rachael N. Labitt,Christian Gaebler,Christian Gaebler,Paola Marcovecchio,Reha Baris Incesu,Thomas Eisenreich,Paul D. Bieniasz,Paul D. Bieniasz,Michael S. Seaman,Pamela J. Bjorkman,Jeffrey V. Ravetch,Alexander Ploss,Michel C. Nussenzweig,Michel C. Nussenzweig +29 more
TL;DR: Combinations of potent monoclonal antibodies can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeutic modality in HIV- 1-infected individuals.
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Expression of the Epstein-Barr virus nuclear antigen-1 (EBNA-1) in the mouse can elicit the production of anti-dsDNA and anti-Sm antibodies.
Krishnan Sundar,Sabine Jacques,Paul Gottlieb,Paul Gottlieb,Raquel Villars,Mary-Ellen Benito,Devon K. Taylor,Linda Spatz,Linda Spatz +8 more
TL;DR: It is reported for the first time that expression of the entire EBNA-1 protein in the mouse can elicit the production of IgG antibodies to Sm and to double-stranded DNA (dsDNA), which supports a possible association between EBV infection and SLE.
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Bromocriptine restores tolerance in estrogen-treated mice
TL;DR: The estradiol-induced breakdown in B-cell tolerance can be abrogated by bromocriptine, which induces anergy in the high-affinity DNA-reactive B cells.
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Induction of tolerance to an IgG autoantibody.
TL;DR: Nonautoimmune mice transgenic for the heavy chain of an IgG2b anti-double-stranded-DNA antibody express the transgene in lymphoid organs and display partial allelic exclusion of this gamma 2b transgenes, demonstrating the induction of self tolerance to an Igg autoantibody.
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Reduced adult neurogenesis and altered emotional behaviors in autoimmune-prone B-cell activating factor transgenic mice.
Rosalia Crupi,Marco Cambiaghi,Linda Spatz,René Hen,Mitchell Thorn,Eitan Friedman,Giuseppe Vita,Fortunato Battaglia,Fortunato Battaglia +8 more
TL;DR: The results suggest that anxiety associated with autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and Sjögren's syndrome can be linked to brain inflammation, impaired neurogenesis, and hippocampal plasticity.