Louise Fraser

TL;DR: It is shown that the protocol developed for these instruments successfully recaptures known biological results, and additionally that biological conclusions are consistent across sequencing platforms (the HiSeq2000 versus the MiSeq) and across the sequenced regions of amplicons.

TL;DR: An approach that generates several billion bases of accurate nucleotide sequence per experiment at low cost is reported, effective for accurate, rapid and economical whole-genome re-sequencing and many other biomedical applications.

TL;DR: Whole-genome sequencing can provide clinically relevant data within a time frame that can influence patient care and the need for automated data interpretation and the provision of clinically meaningful reports represent hurdles to clinical implementation.

TL;DR: This work describes an algorithm tailored for short-read data from single cells that improves assembly through the use of a progressively increasing coverage cutoff, enabling acquisition of genome assemblies for individual uncultivated bacteria using only short reads.

TL;DR: In this paper, the authors propose a method for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each poynucleotide can be determined.