Gerardo Turcatti

TL;DR: An approach that generates several billion bases of accurate nucleotide sequence per experiment at low cost is reported, effective for accurate, rapid and economical whole-genome re-sequencing and many other biomedical applications.

TL;DR: These new surface amplification processes are seen as an interesting approach for attachment of DNA molecules by their 5'-end on a solid support and can be used as an alternative route for producing DNA chips for genomic studies.

TL;DR: In this article, the authors propose a method for the amplification and sequencing of at least one nucleic acid comprising the following steps: (1) forming at least a template comprising the nucleic acids to be amplified or sequenced; (2) mixing the template(s) with one or more colony primers X, which can hybridize to the oligonucleotide sequence Z and carries at the 5′ end a means for attaching the primers to a solid support, in the presence of a solid supports so that the 5' ends of both the nuclei acid template

TL;DR: The discovery and characterization of small-molecule antagonists that inhibit the stimulator of interferon genes (STING) protein may help to develop therapies for the treatment of autoinflammatory disease.

TL;DR: In this article, the authors propose a set of principles to facilitate the definition and development of disease-relevant assays, and discuss new opportunities for exploiting the latest advances in cell-based assay technologies in drug discovery.