L
Ludo Pagie
Researcher at Netherlands Cancer Institute
Publications - 32
Citations - 6467
Ludo Pagie is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Chromatin & Nuclear lamina. The author has an hindex of 23, co-authored 32 publications receiving 5675 citations. Previous affiliations of Ludo Pagie include Santa Fe Institute & Utrecht University.
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Journal ArticleDOI
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
Lars Guelen,Ludo Pagie,Emilie Brasset,Wouter Meuleman,Wouter Meuleman,Marius B. Faza,Wendy Talhout,Bert H.J. Eussen,Annelies de Klein,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Wouter de Laat,Bas van Steensel +12 more
TL;DR: A high-resolution map of the interaction sites of the entire genome with NL components in human fibroblasts is constructed and demonstrates that the human genome is divided into large, discrete domains that are units of chromosome organization within the nucleus.
Journal ArticleDOI
Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation
Daan Peric-Hupkes,Wouter Meuleman,Wouter Meuleman,Ludo Pagie,Sophia W.M. Bruggeman,Irina Solovei,Wim Brugman,Stefan Gräf,Paul Flicek,Ron M. Kerkhoven,Maarten van Lohuizen,Marcel J. T. Reinders,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Bas van Steensel +14 more
TL;DR: High-resolution maps of genome-nuclear lamina interactions during subsequent differentiation of mouse embryonic stem cells via lineage-committed neural precursor cells into terminally differentiated astrocytes suggest that lamina-genome interactions are widely involved in the control of gene expression programs during lineage commitment and terminal differentiation.
Journal ArticleDOI
Single-Cell Dynamics of Genome-Nuclear Lamina Interactions
Jop Kind,Ludo Pagie,Havva Ortabozkoyun,Shelagh Boyle,Sandra S. de Vries,Hans Janssen,Mario Amendola,Leisha D. Nolen,Wendy A. Bickmore,Bas van Steensel +9 more
TL;DR: The H3K9 methyltransferase G9a is identified as a regulator of NL contacts and contact of individual LADs with the NL is linked to transcriptional repression and H 3K9 dimethylation in single cells.
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Chemical warfare between microbes promotes biodiversity
TL;DR: It is suggested that antibiotic interactions within microbial communities may be very effective in maintaining diversity, based on a spatially explicit game theoretical model with multiply cyclic dominance structures.
Journal ArticleDOI
Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence
Wouter Meuleman,Daan Peric-Hupkes,Jop Kind,Jean-Bernard Beaudry,Ludo Pagie,Manolis Kellis,Manolis Kellis,Marcel J. T. Reinders,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Bas van Steensel +10 more
TL;DR: Results reveal that the spatial organization of mammalian genomes is highly conserved and tightly linked to local nucleotide composition.