L
Ludovic Vallier
Researcher at University of Cambridge
Publications - 199
Citations - 17332
Ludovic Vallier is an academic researcher from University of Cambridge. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 55, co-authored 180 publications receiving 14503 citations. Previous affiliations of Ludovic Vallier include Wellcome Trust & Columbia University.
Papers
More filters
Posted ContentDOI
Analysis of Endothelial-to-Haematopoietic Transition at the Single Cell Level identifies Cell Cycle Regulation as a Driver of Differentiation
Giovanni Canu,Emmanouil Athanasiadis,Rodrigo A. Grandy,Jose Garcia-Bernardo,Paulina M. Strzelecka,Ludovic Vallier,Daniel Ortmann,Ana Cvejic +7 more
TL;DR: A direct link between the molecular machineries that control cell cycle progression and EHT is proposed and it is demonstrated that CDK4/6 and CDK1 play a key role not only in the transition but also in allowing haematopoietic progenitors to establish their full differentiation potential.
Posted ContentDOI
Unravelling the developmental roadmap towards human brown adipose tissue
Stefania Carobbio,Anne-Claire Guenantin,Myriam Bahri,Isabella Samuelson,Floris Honig,Sonia Rodríguez-Fdez,Kathleen Long,Ioannis Kamzolas,Sherine Awad,Dunja Lukovic,Slaven Erceg,Andrew R. Bassett,Sasha Mendjan,Ludovic Vallier,Barry Rosen,Davide Chiarugi,Antonio Vidal-Puig +16 more
TL;DR: A human-relevant new protocol for the differentiation of human pluripotent stem cells into brown adipocytes (BAs) that is chemically-defined to recapitulate a physiological step-by-step developmental path of BAT that captures transient paraxial mesoderm and BAT progenitor states, on its way to reaching the adipocyte stage finally.
Journal ArticleDOI
Modeling Nonalcoholic Fatty Liver Disease in the Dish Using Human-Specific Platforms: Strategies and Limitations
TL;DR: In this article , the authors review different platforms for their strengths and limitations in modeling NAFLD and highlight the shortcoming of current models to recapitulate the complexity of inter-organ crosstalk and the chronic process of liver fibrosis-to-cirrhosis.
Patent
Procédé de différenciation hépatique de cellules endodermiques définitives
TL;DR: The presente invention concerne un procede d'obtention d'une population de cellules progenitrices hepatiques, ledit procede comprenant une etape consistant a cultiver des cellules endodermiques definitives avec un milieu de culture stimulant the specification hepatique.