L
Ludovic Vallier
Researcher at University of Cambridge
Publications - 199
Citations - 17332
Ludovic Vallier is an academic researcher from University of Cambridge. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 55, co-authored 180 publications receiving 14503 citations. Previous affiliations of Ludovic Vallier include Wellcome Trust & Columbia University.
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Journal ArticleDOI
HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells.
Natasha Hui Jin Ng,Joanita Binte Jasmen,Chang Siang Lim,Hwee Hui Lau,Hwee Hui Lau,Vidhya Gomathi Krishnan,Juned Kadiwala,Rohit N. Kulkarni,Helge Ræder,Helge Ræder,Ludovic Vallier,Ludovic Vallier,Shawn Hoon,Adrian Kee Keong Teo,Adrian Kee Keong Teo,Adrian Kee Keong Teo +15 more
TL;DR: The results suggest that in MODY1, liver and pancreas development is perturbed early on, contributing to altered hepatic proteins and β cell defects in patients.
Journal ArticleDOI
GATA6 cooperates with EOMES/SMAD2/3 to deploy the gene regulatory network governing human definitive endoderm and pancreas formation
Crystal Y. Chia,Crystal Y. Chia,Pedro Madrigal,Simon Denil,Iker Martinez,Jose Garcia-Bernardo,Ranna El-Khairi,Mariya Chhatriwala,Maggie Shepherd,Andrew T. Hattersley,N. Ray Dunn,N. Ray Dunn,Ludovic Vallier,Ludovic Vallier +13 more
TL;DR: GATA6 is positioned as a gatekeeper to early human, but not murine, pancreatic ontogeny by genome-wide studies show that GATA6 binds and cooperates with EOMES/SMAD2/3 to regulate the expression of cardinal endoderm genes.
Journal ArticleDOI
Analysis of endothelial-to-haematopoietic transition at the single cell level identifies cell cycle regulation as a driver of differentiation
Giovanni Canu,Giovanni Canu,Emmanouil Athanasiadis,Emmanouil Athanasiadis,Emmanouil Athanasiadis,Rodrigo A. Grandy,Rodrigo A. Grandy,Jose Garcia-Bernardo,Paulina M. Strzelecka,Paulina M. Strzelecka,Paulina M. Strzelecka,Ludovic Vallier,Ludovic Vallier,Daniel Ortmann,Daniel Ortmann,Ana Cvejic,Ana Cvejic,Ana Cvejic +17 more
TL;DR: A direct link between the molecular machineries that control cell cycle progression and EHT is proposed and it is demonstrated that CDK4/6 and CDK1 play a key role not only in the transition but also in allowing haematopoietic progenitors to establish their full differentiation potential.
Journal ArticleDOI
Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs
Helena Kilpinen,Angela Goncalves,Andreas Leha,Vackar Afzal,Kaur Alasoo,Sofie Ashford,Sendu Bala,Dalila Bensaddek,Francesco Paolo Casale,Oliver J. Culley,Petr Danecek,Adam Faulconbridge,Peter W. Harrison,Annie Kathuria,Davis J. McCarthy,Shane A. McCarthy,Ruta Meleckyte,Yasin Memari,Nathalie Moens,Filipa A.C. Soares,Alice L. Mann,Ian Streeter,Chukwuma A. Agu,Alex Alderton,Rachel Nelson,Sarah Harper,Minal Patel,A. White,Sharad R. Patel,Laura Clarke,Reena Halai,Christopher M. Kirton,Anja Kolb-Kokocinski,Philip L. Beales,Ewan Birney,Davide Danovi,Angus I. Lamond,Willem H. Ouwehand,Ludovic Vallier,Fiona M. Watt,Richard Durbin,Oliver Stegle,Daniel J. Gaffney +42 more
TL;DR: This corrects the article DOI: 10.1038/nature22403 to indicate that the author of the paper is a scientist rather than a scientist-in-residence, as previously reported.
Journal ArticleDOI
Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation.
Daniel Ortmann,Stephanie Brown,Anne Czechanski,Selcan Aydin,Daniele Muraro,Yuanhua Huang,Rute A. Tomaz,Anna Osnato,Giovanni Canu,Brandon T Wesley,Daniel A. Skelly,Oliver Stegle,Ted Choi,Gary A. Churchill,Christopher L. Baker,Peter J. Rugg-Gunn,Steven C. Munger,Laura G. Reinholdt,Ludovic Vallier +18 more
TL;DR: Overall, this study shows that genetic background plays a dominant role in driving phenotypic variability of PSCs, explained in part through inconsistent activity of extra-cellular signaling, including the Wnt pathway, which is modulated by specific genetic variants.