L
Ludovic Vallier
Researcher at University of Cambridge
Publications - 199
Citations - 17332
Ludovic Vallier is an academic researcher from University of Cambridge. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 55, co-authored 180 publications receiving 14503 citations. Previous affiliations of Ludovic Vallier include Wellcome Trust & Columbia University.
Papers
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Journal ArticleDOI
Induced pluripotent stem cells- alchemist's tale or clinical reality?
S. Tamir Rashid,Ludovic Vallier +1 more
TL;DR: A review of the historical development, current technologies and potential clinical applications of induced pluripotency and a perspective on the possible future directions for this dynamic field of stem cell research are given.
Book ChapterDOI
Serum-free and feeder-free culture conditions for human embryonic stem cells.
TL;DR: The basic principles of growing hESCs in a chemically defined medium (CDM) devoid of serum and feeders are described.
Journal ArticleDOI
Integration-deficient lentivectors: an effective strategy to purify and differentiate human embryonic stem cell-derived hepatic progenitors
Guanghua Yang,Guanghua Yang,Karim Si-Tayeb,Karim Si-Tayeb,Sébastien Corbineau,Sébastien Corbineau,Rémi Vernet,Régis Gayon,Noushin Dianat,Noushin Dianat,Clémence Martinet,Clémence Martinet,Denis Clay,Denis Clay,Sylvie Goulinet-Mainot,Sylvie Goulinet-Mainot,Gérard Tachdjian,Deborah J. Burks,Ludovic Vallier,Pascale Bouillé,Anne Dubart-Kupperschmitt,Anne Dubart-Kupperschmitt,Anne Weber,Anne Weber +23 more
TL;DR: An effective strategy to purify human hepatic cells from cultures of differentiating hPSCs is developed, producing a novel tool that could be used not only for cell therapy but also for in vitro applications such as drug screening.
Journal ArticleDOI
Generation of Distal Airway Epithelium from Multipotent Human Foregut Stem Cells
Nicholas R.F. Hannan,Fotios Sampaziotis,Charis-Patricia Segeritz,Neil A. Hanley,Ludovic Vallier,Ludovic Vallier +5 more
TL;DR: This study establishes a new approach for the generation of functional lung cells that can be used for disease modeling as well as for drug screening and the study of lung development, and is the first demonstration that multipotent endoderm stem cells can differentiate not only into both liver and pancreatic cells but also into lung endODerm.
Patent
Differentiation of pluripotent cells into primary germ layer progenitors
TL;DR: In this paper, the authors describe the culture of pluripotent cells in a fully humanised chemically defined medium, where cells may be cultured over a prolonged period of time and can be controllably induced to differentiate into progenitor cells of the three primary germ layers by the addition of differentiation factors.