L
Ludovic Vallier
Researcher at University of Cambridge
Publications - 199
Citations - 17332
Ludovic Vallier is an academic researcher from University of Cambridge. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 55, co-authored 180 publications receiving 14503 citations. Previous affiliations of Ludovic Vallier include Wellcome Trust & Columbia University.
Papers
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Journal ArticleDOI
Human stem cells for craniomaxillofacial reconstruction.
Morteza Jalali,William Niall Alexander Kirkpatrick,Malcolm Gregor Cameron,Siim Pauklin,Ludovic Vallier +4 more
TL;DR: An overview of human stem cells in disease modeling, drug screening, and therapeutics, while also discussing the application of regenerative medicine for craniomaxillofacial tissue deficit and surgical reconstruction is provided.
Journal ArticleDOI
Heps with pep: direct reprogramming into human hepatocytes.
TL;DR: Two papers demonstrate efficient direct reprogramming of human fibroblasts into induced hepatocytes, which exhibit metabolic properties similar to primary hepatocytes.
Journal ArticleDOI
TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells.
Anna Osnato,Stephanie Brown,Christel Krueger,Simon Andrews,Amanda J. Collier,Shota Nakanoh,Shota Nakanoh,Mariana Quiroga Londoño,Brandon T Wesley,Daniele Muraro,Daniele Muraro,A Sophie Brumm,Kathy K. Niakan,Kathy K. Niakan,Ludovic Vallier,Daniel Ortmann,Peter J. Rugg-Gunn,Peter J. Rugg-Gunn +17 more
TL;DR: In this article, the authors demonstrate that TGFβ signalling is required to maintain naive human pluripotent stem cells (hPSCs) and that the downstream effector proteins - SMAD2/3 - bind common sites in naive and primed hPSCs, including shared pluripotency genes.
Posted ContentDOI
Common genetic variation drives molecular heterogeneity in human iPSCs
Helena Kilpinen,Angela Goncalves,Andreas Leha,Vackar Afzal,Sofie Ashford,Sendu Bala,Dalila Bensaddek,Francesco Paolo Casale,Oliver J. Culley,Petr Danacek,Adam Faulconbridge,Peter W. Harrison,Davis J. McCarthy,Davis J. McCarthy,Shane A. McCarthy,Ruta Meleckyte,Yasin Memari,Nathalie Moens,Filipa A.C. Soares,Ian Streeter,Chukwuma A. Agu,Alex Alderton,Rachel Nelson,Sarah Harper,Minal Patel,Laura Clarke,Reena Halai,Christopher M. Kirton,Anja Kolb-Kokocinski,Philip L. Beales,Ewan Birney,Davide Danovi,Angus I. Lamond,Willem H. Ouwehand,Ludovic Vallier,Fiona M. Watt,Richard Durbin,Oliver Stegle,Daniel J. Gaffney +38 more
TL;DR: This study provides a comprehensive picture of the major sources of genetic and phenotypic variation in iPSCs and establishes their suitability for use in genetic studies of complex human traits and cancer.
Patent
Pluripotent cells from the mammalian late epiblast layer
TL;DR: The Epiblast Stem Cells' (EpiSCs) as discussed by the authors are derived from the mammalian late epiblast layer and are useful in a range of applications, including the generation of transgenic animal species.