L
Ludovic Vallier
Researcher at University of Cambridge
Publications - 199
Citations - 17332
Ludovic Vallier is an academic researcher from University of Cambridge. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 55, co-authored 180 publications receiving 14503 citations. Previous affiliations of Ludovic Vallier include Wellcome Trust & Columbia University.
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Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development
Thomas Touboul,Nicholas R.F. Hannan,Sébastien Corbineau,Amelie Martinez,Clémence Martinet,Sophie Branchereau,Sylvie Mainot,Helene Strick-Marchand,Roger A. Pedersen,James P. Di Santo,Anne Weber,Ludovic Vallier +11 more
TL;DR: A robust and efficient method to differentiate pluripotent stem cells into hepatic cells, which exhibit characteristics of human hepatocytes are reported, which should facilitate the development of clinical grade hepatocytes for transplantation and for research on drug discovery.
Journal ArticleDOI
Common genetic variation drives molecular heterogeneity in human iPSCs
Helena Kilpinen,Angela Goncalves,Andreas Leha,Vackar Afzal,Kaur Alasoo,Sofie Ashford,Sendu Bala,Dalila Bensaddek,Francesco Paolo Casale,Oliver J. Culley,Petr Danacek,Adam Faulconbridge,Peter W. Harrison,Annie Kathuria,Davis J. McCarthy,Davis J. McCarthy,Shane A. McCarthy,Ruta Meleckyte,Yasin Memari,Nathalie Moens,Filipa A.C. Soares,Alice L. Mann,Ian Streeter,Chukwuma A. Agu,Alex Alderton,Rachel Nelson,Sarah Harper,Minal Patel,A. White,Sharad R. Patel,Laura Clarke,Reena Halai,Christopher M. Kirton,Anja Kolb-Kokocinski,Philip L. Beales,Ewan Birney,Davide Danovi,Angus I. Lamond,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Ludovic Vallier,Ludovic Vallier,Fiona M. Watt,Richard Durbin,Oliver Stegle,Daniel J. Gaffney +46 more
TL;DR: This study outlines the major sources of genetic and phenotypic variation in iPS cells and establishes their suitability as models of complex human traits and cancer.
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The Cell-Cycle State of Stem Cells Determines Cell Fate Propensity
TL;DR: Using the FUCCI reporter system in human pluripotent stem cells is used to demonstrate that cell fate decisions are tightly associated with the cell-cycle machinery and reveal insights in the mechanisms synchronizing differentiation and proliferation in developing tissues.
Journal ArticleDOI
Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
Ludovic Vallier,Sasha Mendjan,Stephanie Brown,Zhenzhi Chng,Adrian Kee Keong Teo,Lucy E. Smithers,Matthew Trotter,Matthew Trotter,Candy H.-H. Cho,Amelie Martinez,Peter J. Rugg-Gunn,Gabrielle Brons,Roger A. Pedersen +12 more
TL;DR: It is demonstrated that Activin/Nodal signalling controls expression of the key pluripotency factor Nanog in human ESCs and in mouse EpiSCs, which prevents neuroectoderm differentiation induced by FGF signalling and limits the transcriptional activity of the Smad2/3 cascade, blocking progression along the endoderm lineage.
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Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway
TL;DR: Analysis of the Nodal-expressing phenotype suggests a function for the transforming growth factor-beta (TGF-beta) growth factor superfamily in pluripotency and in early cell fate decisions leading to primary tissue layers during in vitro development of pluripotent human stem cells.