L
Ludovic Vallier
Researcher at University of Cambridge
Publications - 199
Citations - 17332
Ludovic Vallier is an academic researcher from University of Cambridge. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 55, co-authored 180 publications receiving 14503 citations. Previous affiliations of Ludovic Vallier include Wellcome Trust & Columbia University.
Papers
More filters
Journal ArticleDOI
Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis
Michael N. Weedon,Inês Cebola,Ann-Marie Patch,Sarah E. Flanagan,Elisa De Franco,Richard Caswell,Santiago A. Rodríguez-Seguí,Charles Shaw-Smith,Candy H.-H. Cho,Hana Lango Allen,Jayne A L Houghton,Christian L. Roth,Rongrong Chen,Khalid Hussain,Phil Marsh,Ludovic Vallier,Anna Murray,Sian Ellard,Jorge Ferrer,Andrew T. Hattersley +19 more
TL;DR: This analysis uncovered six different recessive mutations in a previously uncharacterized ∼400-bp sequence located 25 kb downstream of PTF1A (encoding pancreas-specific transcription factor 1a) in ten families with pancreatic agenesis.
Journal ArticleDOI
The SMAD2/3 interactome reveals that TGFβ controls m 6 A mRNA methylation in pluripotency
Alessandro Bertero,Stephanie Brown,Pedro Madrigal,Pedro Madrigal,Anna Osnato,Daniel Ortmann,Loukia Yiangou,Juned Kadiwala,Nina C. Hubner,Igor Ruiz de los Mozos,Christoph Yves Sadée,An-Sofie Lenaerts,Shota Nakanoh,Rodrigo A. Grandy,Edward J. Farnell,Jernej Ule,Hendrik G. Stunnenberg,Sasha Mendjan,Ludovic Vallier,Ludovic Vallier +19 more
TL;DR: This analysis reveals that SMAD2/3 is involved in multiple molecular processes in addition to its role in transcription, and reveals the mechanism by which extracellular signalling can induce rapid cellular responses through regulation of the epitranscriptome.
Journal ArticleDOI
Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability
Anna-Claire Devlin,Karen Burr,Shyamanga Borooah,Joshua D. Foster,Elaine M. Cleary,Imbisaat Geti,Ludovic Vallier,Christopher Shaw,Siddharthan Chandran,Gareth B. Miles +9 more
TL;DR: It is demonstrated that MNs derived from iPSCs obtained from healthy individuals or patients harbouring TARDBP or C9ORF72 ALS-causing mutations are able to develop appropriate physiological properties, but patient iPSC-derived MNs, independent of genotype, display an initial hyperexcitability followed by progressive loss of action potential output and synaptic activity.
Journal ArticleDOI
Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells
Jessica L. Forbester,David Goulding,Ludovic Vallier,Ludovic Vallier,Nicholas R.F. Hannan,Christine Hale,Derek Pickard,Subhankar Mukhopadhyay,Gordon Dougan +8 more
TL;DR: Evidence is provided that hIPSC-derived organoids are a promising model of the intestinal epithelium for assessing interactions with enteric pathogens.
Journal ArticleDOI
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
Anna S E Cuomo,Daniel D Seaton,Davis J. McCarthy,Davis J. McCarthy,Iker Martinez,Marc Jan Bonder,Marc Jan Bonder,Jose Garcia-Bernardo,Shradha Amatya,Pedro Madrigal,Abigail Isaacson,Florian Buettner,Andrew J Knights,Kedar Nath Natarajan,Kedar Nath Natarajan,Ludovic Vallier,Ludovic Vallier,John C. Marioni,John C. Marioni,John C. Marioni,Mariya Chhatriwala,Oliver Stegle,Oliver Stegle +22 more
TL;DR: Induced pluripotent stem cells from 125 donors are exploited to track gene expression changes and expression quantitative trait loci at single cell resolution during in vitro endoderm differentiation to identify molecular markers that are predictive of differentiation efficiency of individual lines.