L
Ludovic Vallier
Researcher at University of Cambridge
Publications - 199
Citations - 17332
Ludovic Vallier is an academic researcher from University of Cambridge. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 55, co-authored 180 publications receiving 14503 citations. Previous affiliations of Ludovic Vallier include Wellcome Trust & Columbia University.
Papers
More filters
Book ChapterDOI
Signaling Pathways in Embryonic Stem Cells
TL;DR: This chapter covers the different signaling pathways affecting embryonic stem (ES) cells, and the developmental context of pluripotent tissue, which gives useful insights for the derivation and culture of ES cells as well as for directed differentiation to adult tissues.
Journal ArticleDOI
Generation of functional hepatocytes by forward programming with nuclear receptors
Rute A. Tomaz,Ekaterini D. Zacharis,Fabian Bachinger,Annabelle Wurmser,Daniel Yamamoto,Sandra Petrus-Reurer,Carola M. Morell,Dominika Dziedzicka,Brandon T Wesley,Imbisaat Geti,Charis-P. Segeritz,Miguel Cardoso de Brito,Mariya Chhatriwala,Daniel Ortmann,Kourosh Saeb-Parsy,Ludovic Vallier +15 more
TL;DR: The results show that forward programming could offer a versatile alternative to direct differentiation for generating hepatocytes in vitro and to bypass limitations of directed differentiation of human pluripotent stem cells into hepatocyte-like cells (HLCs).
Journal ArticleDOI
Genotype-phenotype analysis across 130 422 genetic variants identifies RSPO3 as the first genome-wide significant modifier gene in primary sclerosing cholangitis
Rudi Alberts,E. M. de Vries,Graeme J.M. Alexander,Domenico Alvaro,Annika Bergquist,Ulrich Beuers,Einar Bjornsson,Kirsten Muri Boberg,Christopher L. Bowlus,Roger W. Chapman,Olivier Chazouillères,Angela M. Cheung,G.N. Dalekos,Bertus Eksteen,David Ellinghaus,Martti Färkkilä,Eleonora A. M. Festen,A. Floreani,Trine Folseraas,E. Goode,Daniel Gotthardt,Gideon M. Hirschfield,B. van Hoek,Kristian Holm,S. Hohenester,Johannes R. Hov,Floris Imhann,Pietro Invernizzi,Xiaojun Jiang,John E. Eaton,Brian D. Juran,Konstantinos N. Lazaridis,Virpi Leppa,Jimmy Z. Liu,J. Lofberg,Michael P. Manns,Hanns-Ulrich Marschall,Marco Marzioni,Andrew Mason,Espen Melum,Piotr Milkiewicz,Tobias Müller,Albert Parés,Christian Rupp,S. M. Rushbrook,Christian Rust,F. Sampaziotis,Richard Sandford,Christoph Schramm,Stefan Schreiber,E. Schrumpf,Mark S. Silverberg,Brijesh Srivastava,Martina Sterneck,Andreas Teufel,L. Tittmann,Ludovic Vallier,Arnau Vich Vila,B. de Vries,Tobias J. Weismüller,Cisca Wijmenga,Kalliopi Zachou,Andre Franke,Carl A. Anderson,Tom H. Karlsen,Cyriel Y. Ponsioen,Rinse K. Weersma +66 more
TL;DR: This study presents a pragmatic approach for effective rare CNV screening of SNP-array data sets and implicates the potential contribution of rare structural variants in the pathogenesis of UC.
Journal ArticleDOI
Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease
Anna Speicher,Lisanne Korn,Júlia Csatári,Laura Gonzalez-Cano,Michael Heming,Christian Thomas,Christina B. Schroeter,David Schafflick,Xiaolin Li,Lukáš Gola,Alexander Engler,Thilo Kaehne,Ludovic Vallier,Sven G. Meuth,Gerd Meyer zu Hörste,Stjepana Kovac,Heinz Wiendl,Hans R. Schöler,Matthias Pawlowski +18 more
TL;DR: The microglia forward programming platform represents a tool for both reductionist studies in monocultures and complex coculture systems, including 3D brain organoids for the study of cellular interactions in healthy or diseased environments.
Book ChapterDOI
Use of Biliary Organoids in Cholestasis Research
TL;DR: Two methods for growing human cholangiocytes in organoid format are described, one for the generation of intrahepatic bile ducts using human induced pluripotent stem cells and the other for the propagation of primary biliary epithelium from the extrahePatic ducts or gallbladder.