M. Molla

TL;DR: This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity in carriers of the minor (Asn) allele.

TL;DR: The comprehensive centralised database and linked biobank is a valuable resource for the radiotherapy community for validating predictive models and biomarkers and will also enable a better understanding of how many people suffer with radiotherapy toxicity.

TL;DR: It is found that pre-treatment with ataxia telangiectasia and Rad3 related (ATR) inhibitors, which targets response to replication stress, significantly enhanced the sensitivity of tetraploid cells to first-line chemotherapeutic agents as well as to ionizing radiation, and it is shown that ATR inhibitors can sensitize near-tetraploids cells to commonly used chemo-radiotherapy regimens.

TL;DR: Non-adherence to radiotherapy, as measured by the received dose, is very low in this setting, and it may have an impact on one-year survival, and the risk of death in non-adherent patients was higher than in adherent patients.

TL;DR: A moderate pain response tailored to life expectancy can be obtained in patients treated with radiation, and 8-Gy single-dose RT is an option for patients with limited survival.