M
Maciek R. Antoniewicz
Researcher at University of Delaware
Publications - 93
Citations - 7954
Maciek R. Antoniewicz is an academic researcher from University of Delaware. The author has contributed to research in topics: Metabolic flux analysis & Pentose phosphate pathway. The author has an hindex of 47, co-authored 89 publications receiving 6638 citations. Previous affiliations of Maciek R. Antoniewicz include Massachusetts Institute of Technology & University of Michigan.
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Journal ArticleDOI
Elementary metabolite units (EMU): A novel framework for modeling isotopic distributions
TL;DR: This work presents a novel framework for the modeling of isotopic labeling systems that significantly reduces the number of system variables without any loss of information and is most efficient for the analysis of labeling by multiple isotopic tracers.
Journal ArticleDOI
A roadmap for interpreting 13 C metabolite labeling patterns from cells
Joerg Martin Buescher,Maciek R. Antoniewicz,Laszlo G. Boros,Shawn C. Burgess,Henri Brunengraber,Clary B. Clish,Ralph J. DeBerardinis,Olivier Feron,Christian Frezza,Bart Ghesquière,Eyal Gottlieb,Karsten Hiller,Russell G. Jones,Jurre J. Kamphorst,Richard G. Kibbey,Alec C. Kimmelman,Jason W. Locasale,Sophia Y. Lunt,Oliver D. K. Maddocks,Craig R. Malloy,Christian M. Metallo,Emmanuelle J. Meuillet,Joshua Munger,Katharina Nöh,Joshua D. Rabinowitz,Markus Ralser,Markus Ralser,Uwe Sauer,Gregory Stephanopoulos,Julie St-Pierre,Daniel A. Tennant,Christoph Wittmann,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Alexei Vazquez,Karen H. Vousden,Jamey D. Young,Nicola Zamboni,Sarah-Maria Fendt +38 more
TL;DR: Key issues in interpreting (13)C metabolite labeling patterns are reviewed, with the goal of drawing accurate conclusions from steady state and dynamic stable isotopic tracer experiments.
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Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements.
TL;DR: An efficient algorithm is developed to determine accurate flux confidence intervals and it is demonstrated that confidence intervals obtained with this method closely approximate true flux uncertainty.
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Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
Dannielle C. DeWaal,Veronique Nogueira,Alexander R. Terry,Krushna C. Patra,Krushna C. Patra,Sang-Min Jeon,Sang-Min Jeon,Grace Guzman,Jennifer Au,Christopher P. Long,Maciek R. Antoniewicz,Nissim Hay,Nissim Hay +12 more
TL;DR: It is shown that HK2 ablation decreases glycolysis and triggers oxidative phosphorylation (OXPHO) rendering HCC more susceptible to the OXPHO inhibitor metformin and to the FDA-approved drug sorafenib.
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Quantifying Reductive Carboxylation Flux of Glutamine to Lipid in a Brown Adipocyte Cell Line
TL;DR: A new role for glutamine as a lipogenic precursor is demonstrated and an alternative to the glutaminolysis pathway where flux of glutamine to lipogenic acetyl-CoA occurs via reductive carboxylation is proposed.