M
Maddalena Scotti
Researcher at University of Urbino
Publications - 11
Citations - 375
Maddalena Scotti is an academic researcher from University of Urbino. The author has contributed to research in topics: Ascorbic acid & Mitochondrion. The author has an hindex of 8, co-authored 11 publications receiving 353 citations.
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Journal ArticleDOI
Gene expression profiles of epithelial cells microscopically isolated from a breast-invasive ductal carcinoma and a nodal metastasis
Ileana Zucchi,E. Mento,Vladimir A. Kuznetsov,Maddalena Scotti,V. Valsecchi,Barbara Simionati,E. Vicinanza,Giorgio Valle,S. Pilotti,Rolland Reinbold,Paolo Vezzoni,Alberto Albertini,Renato Dulbecco +12 more
TL;DR: It is shown that the expression profiles obtained are exclusive of carcinoma cells with no contribution of non-epithelial cells, suggesting that the down-regulation of a set of genes may be the basic mechanism of cancer formation, while the up-regulation may characterize and possibly control the state of evolution of individual cancers.
Journal ArticleDOI
The properties of a mammary gland cancer stem cell
Ileana Zucchi,S. Sanzone,Simonetta Astigiano,Paride Pelucchi,Maddalena Scotti,V. Valsecchi,Ottavia Barbieri,Gloria Bertoli,Alberto Albertini,Rolland Reinbold,Renato Dulbecco +10 more
TL;DR: The properties of self-renewal, extensive capacity for proliferation, multilineage differentiation potential, and single-cell tumor-initiation potential suggest that LA7 cells are cancer stem cells and can be used as a model system to study the dynamics of tumor formation at the single- cell level.
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TBX3, the gene mutated in ulnar-mammary syndrome, promotes growth of mammary epithelial cells via repression of p19ARF, independently of p53
Natalia Platonova,Maddalena Scotti,Polina Babich,Gloria Bertoli,Elena Mento,Vasco Meneghini,Aliana Egeo,Ileana Zucchi,Giorgio R. Merlo +8 more
TL;DR: Data is provided showing the growth-promoting function of Tbx3 in several models of MECs, in association with its ability to repress the ARF promoter, the first direct evidence that the level of T bx3 expression positively controls the proliferation of M ECs via pathways alternative to Mdm2-p53.
Journal ArticleDOI
The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium.
Mara Fiorani,Catia Azzolini,Liana Cerioni,Maddalena Scotti,Andrea Guidarelli,Caterina Ciacci,Orazio Cantoni +6 more
TL;DR: The results presented in this study indicate that the U937 cell mitochondrial transporter of AA, because of its very low requirement for Na+ and independence for Ca++ and Mg++, displays kinetic characteristics surprisingly similar with those of the plasma membrane SVCT2.
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Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition.
TL;DR: MitoO2-./H2 O2 directly mediates DNA damage induced by arsenite and indirectly promotes the formation of additional DNA-damaging species via the induction of MPT.