Journal ArticleDOI
Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin
Manish Singh,Somanath Kundu,Amarendar Reddy M,Vedagopuram Sreekanth,Rajender K. Motiani,Sagar Sengupta,Aasheesh Srivastava,Avinash Bajaj +7 more
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TLDR
It is noticed that DOX-Gel nanocarriers are especially effective when injected during the early stage of tumor progression, and achieve a substantial decrease in tumor load in the long term.Abstract:
The majority of the localized drug delivery systems are based on polymeric or polypeptide scaffolds, as weak intermolecular interactions of low molecular weight hydrogelators (LMHGs, Mw <500 Da) are significantly perturbed in the presence of anticancer drugs. Here, we present l-alanine derived low molecular weight hydrogelators (LMHGs) that remain injectable even after entrapping the anticancer drug doxorubicin (DOX). These DOX containing nanoassemblies (DOX-Gel) showed promising anticancer activity in mice models. Subcutaneous injection of DOX-Gel near the tumor achieved a greater decrease in tumour load than by intravenous injection of DOX (DOX-IV), and local injection of DOX alone (DOX-Local) at the tumor site. We noticed that DOX-Gel nanocarriers are especially effective when injected during the early stage of tumor progression, and achieve a substantial decrease in tumor load in the long term.read more
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Injectable hydrogel-based drug delivery systems for local cancer therapy
TL;DR: Generally, injectable hydrogel-based drug delivery systems are found to be more efficacious than the conventional systemic chemotherapy in terms of cancer treatment.
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Anticancer drug-loaded hydrogels as drug delivery systems for the local treatment of glioblastoma
TL;DR: An overview on hydrogels loaded with anticancer drugs for the treatment of GBM recently used in preclinical and clinical studies, their advantages and major limitations for clinical translation is provided.
Journal ArticleDOI
Nanocarrier-based systems for targeted and site specific therapeutic delivery.
TL;DR: The present review describes major advantages and limitations of organic and inorganic nanocarriers or living cell-based drug and nucleic acid delivery systems.
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Smart Injectable Hydrogels for Cancer Immunotherapy
Yu Chao,Qian Chen,Zhuang Liu +2 more
TL;DR: Although applied locally, such injectable hydrogel‐based cancer immunotherapy can activate systemic antitumor immune responses, safely and effectively inhibiting the tumor metastasis and recurrence.
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Release of small bioactive molecules from physical gels.
TL;DR: This review summarizes the use of physical (or supramolecular) gels derived from low molecular weight compounds for the encapsulation and controlled release of small therapeutic molecules.
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