M
Manja Koch
Researcher at Harvard University
Publications - 61
Citations - 2597
Manja Koch is an academic researcher from Harvard University. The author has contributed to research in topics: Population & Fatty liver. The author has an hindex of 19, co-authored 61 publications receiving 1716 citations. Previous affiliations of Manja Koch include Brigham and Women's Hospital & University of Kiel.
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Journal ArticleDOI
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
Jun Wang,Louise B. Thingholm,Jurgita Skiecevičienė,Philipp Rausch,Philipp Rausch,Martin Kummen,Johannes R. Hov,Frauke Degenhardt,Femke-Anouska Heinsen,Malte C. Rühlemann,Silke Szymczak,Kristian Holm,Tõnu Esko,Jun Sun,Mihaela Pricop-Jeckstadt,Samer Al-Dury,Pavol Bohov,Jörn Bethune,Felix Sommer,David Ellinghaus,Rolf K. Berge,Rolf K. Berge,Matthias Hübenthal,Manja Koch,Karin Schwarz,Gerald Rimbach,Patricia Hübbe,Wei-Hung Pan,Raheleh Sheibani-Tezerji,Robert Häsler,P Rosenstiel,Mauro D'Amato,Mauro D'Amato,Katja Cloppenborg-Schmidt,Sven Künzel,Matthias Laudes,Hanns-Ulrich Marschall,Wolfgang Lieb,Ute Nöthlings,Tom H. Karlsen,John F. Baines,John F. Baines,Andre Franke +42 more
TL;DR: Genome-wide significant associations for overall microbial variation and individual taxa at multiple genetic loci identify other important points of host–microbe intersection, notably several disease susceptibility genes and sterol metabolism pathway components.
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Dietary pattern analysis and biomarkers of low-grade inflammation: a systematic literature review
Janett Barbaresko,Janett Barbaresko,Manja Koch,Matthias B. Schulze,Ute Nöthlings,Ute Nöthlings +5 more
TL;DR: While results of the studies were inconsistent, interventions with presumed healthy diets resulted in reductions of almost all investigated inflammatory biomarkers, particularly C-reactive protein.
Journal ArticleDOI
Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition.
Louise B. Thingholm,Malte C. Rühlemann,Manja Koch,Brie K. Fuqua,Guido Laucke,Ruwen Boehm,Corinna Bang,Eric A. Franzosa,Eric A. Franzosa,Matthias Hübenthal,Ali Rahnavard,Ali Rahnavard,Fabian Frost,Jason Lloyd-Price,Jason Lloyd-Price,Melanie Schirmer,Melanie Schirmer,Aldons J. Lusis,Chris D. Vulpe,Markus M. Lerch,Georg Homuth,Tim Kacprowski,Tim Kacprowski,Carsten Oliver Schmidt,Ute Nöthlings,Tom H. Karlsen,Tom H. Karlsen,Wolfgang Lieb,Matthias Laudes,Andre Franke,Curtis Huttenhower,Curtis Huttenhower +31 more
TL;DR: Medications, including antihypertensives and antidiabetics, along with dietary supplements including iron, were significantly associated with microbiome variation and identify dietary and medication exposures to consider in future studies.
Journal ArticleDOI
Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease
Jakob M. Bader,Philipp E. Geyer,Philipp E. Geyer,Johannes Müller,Maximilian T. Strauss,Manja Koch,Frank Leypoldt,Peter Koertvelyessy,Peter Koertvelyessy,Daniel Bittner,Carola G. Schipke,Enise I. Incesoy,Oliver Peters,Oliver Peters,Nikolaus Deigendesch,Mikael Simons,Majken K. Jensen,Majken K. Jensen,Henrik Zetterberg,Matthias Mann,Matthias Mann +20 more
TL;DR: A highly reproducible mass spectrometry (MS)‐based proteomics workflow for the in‐depth analysis of CSF from minimal sample amounts is presented and a consistent glycolytic signature across cohorts and a recent study suggests clinical utility of this proteomic signature.
Journal ArticleDOI
Postdiagnosis body mass index and risk of mortality in colorectal cancer survivors: a prospective study and meta-analysis.
Sabrina Schlesinger,Sabine Siegert,Manja Koch,Jessica Walter,Nils Heits,Sebastian Hinz,Gunnar Jacobs,Jochen Hampe,Clemens Schafmayer,Ute Nöthlings,Ute Nöthlings +10 more
TL;DR: The present study as well as single previously published studies showed that overweight was associated with a non-significant reduced risk for all-cause mortality, but the meta-analysis indicated a decreased mortality risk among overweight CRC survivors.