M
Marco A. Marra
Researcher at University of British Columbia
Publications - 657
Citations - 215376
Marco A. Marra is an academic researcher from University of British Columbia. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 153, co-authored 620 publications receiving 184684 citations. Previous affiliations of Marco A. Marra include BC Cancer Agency & University of Washington.
Papers
More filters
Journal ArticleDOI
The Genome of the Steller Sea Lion (Eumetopias jubatus)
Harwood H. Kwan,Luka Culibrk,Gregory A. Taylor,Sreeja Leelakumari,Ryan Tan,Shaun D. Jackman,Kane Tse,Tina MacLeod,Dean Cheng,Eric Chuah,Heather Kirk,Pawan Pandoh,Rebecca Carlsen,Yongjun Zhao,Andrew J. Mungall,Richard D. Moore,Inanc Birol,Marco A. Marra,David A. S. Rosen,Martin Haulena,Steven J.M. Jones +20 more
TL;DR: The Steller sea lion genome is determined through DNA sequencing approaches that utilized microfluidic partitioning library construction, as well as nanopore technologies, and constructed a highly contiguous assembly with a scaffold length of over 14 megabases.
Journal ArticleDOI
Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy.
Yiqun Zhang,Fengju Chen,Erin Pleasance,Laura Williamson,Cameron J. Grisdale,Emma Titmuss,Janessa Laskin,Steven J.M. Jones,Steven J.M. Jones,Isidro Cortes-Ciriano,Marco A. Marra,Chad J. Creighton +11 more
TL;DR: The global impact of structural variants (SVs) on gene regulation in advanced tumors with complex treatment histories has been mostly uncharacterized as discussed by the authors, and a significant fraction of genes with SV-expression associations correlate with worse patient survival in primary and advanced cancers, including SRD5A1 and PLEKHG2.
Journal ArticleDOI
TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L.
Derek Wong,Derek Wong,Lisa Sogerer,Samantha S. Lee,Victor Wong,Amy Lum,Adrian B. Levine,Marco A. Marra,Stephen Yip,Stephen Yip,Stephen Yip +10 more
TL;DR: Functional in vitro studies revealed that loss of ATXN1L leads to the accumulation of polyubiquitinated CIC protein, promoting its degradation through the proteasome, suggesting that the regulation of CIC stability and function is more intricate than previously appreciated and involves several independent pathways.
Journal ArticleDOI
Sequencing Strategies to Guide Decision Making in Cancer Treatment.
TL;DR: In a Perspective, James Topham and Marco Marra discuss progress in the use of genomic information to guide cancer treatment.
Journal ArticleDOI
Genomic Landscape of Pediatric Mixed Phenotype Acute Leukemia
Thomas B. Alexander,Zhaohui Gu,John K. Choi,Mignon L. Loh,John T. Horan,Barbara Buldini,Giuseppe Basso,Sarah Elitzur,C. Michel Zwaan,Valerie de Haas,Allen Eng Juh Yeoh,Dirk Reinhardt,Daisuke Tomizawa,Tim Lammens,Barbara De Moerloose,Li Zhou,Hiroki Hori,Anthony V. Moorman,Andrew S. Moore,Ondrej Hrusak,Soheil Meshinchi,Etan Orgel,Meenakshi Devidas,Stephen P. Hunger,Jaime M. Guidry Auvil,Malcolm A. Smith,Tanja M. Davidsen,Leandro C. Hermida,Patee Gesuwan,Marco A. Marra,Yussanne Ma,Andrew J. Mungall,Richard A. Moore,Daniela S. Gerhard,Xueyuan Cao,Lei Shi,Stanley Pounds,Hiroto Inaba,Charles G. Mullighan +38 more
TL;DR: The goal was to define the molecular basis of MPAL, and to compare with potentially related forms of leukemia (AML, T-ALL and early T-cell precursor (ETP) ALL) as a rational foundation for future trials.