M
Marco A. Marra
Researcher at University of British Columbia
Publications - 657
Citations - 215376
Marco A. Marra is an academic researcher from University of British Columbia. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 153, co-authored 620 publications receiving 184684 citations. Previous affiliations of Marco A. Marra include BC Cancer Agency & University of Washington.
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Journal ArticleDOI
JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data
Andrew Roth,Jiarui Ding,Ryan D. Morin,Anamaria Crisan,Gavin Ha,Ryan Giuliany,Ali Bashashati,Martin Hirst,Gulisa Turashvili,Arusha Oloumi,Marco A. Marra,Samuel Aparicio,Sohrab P. Shah +12 more
TL;DR: Two novel probabilistic graphical models are introduced for jointly analysing paired tumour–normal digital allelic count data from NGS experiments and amplifies the statistical power to identify and distinguish both germline and somatic events in a unified probabilism framework.
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In-depth characterization of the microRNA transcriptome in a leukemia progression model
Florian Kuchenbauer,Ryan D. Morin,Bob Argiropoulos,Oleh Petriv,Malachi Griffith,Michael Heuser,Eric Yung,Jessica Piper,Allen Delaney,Anna-Liisa Prabhu,Yongjun Zhao,Helen McDonald,Thomas Zeng,Martin Hirst,Carl L. Hansen,Marco A. Marra,R. Keith Humphries +16 more
TL;DR: The potential for miRNA-mediated release of oncogenes that facilitates leukemic progression from the preleukemic to leukemia inducing state is revealed and the finding of extensive sequence variations (isomiRs) for almost all miRNA and miRNA species adds additional complexity to the miRNA transcriptome.
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Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors
Steven J.M. Jones,Janessa Laskin,Yvonne Y. Li,Obi L. Griffith,Jianghong An,Mikhail Bilenky,Yaron S. Butterfield,Timothee Cezard,Eric Chuah,Richard Corbett,Anthony P. Fejes,Malachi Griffith,John Yee,Montgomery Martin,Michael Mayo,Nataliya Melnyk,Ryan D. Morin,Trevor J. Pugh,Tesa M. Severson,Sohrab P. Shah,Sohrab P. Shah,Margaret Sutcliffe,Angela Tam,Jefferson Terry,Nina Thiessen,Thomas A. Thomson,Richard Varhol,Thomas Zeng,Yongjun Zhao,Richard A. Moore,David G. Huntsman,Inanc Birol,Martin Hirst,Robert A. Holt,Marco A. Marra +34 more
TL;DR: The utility of massively parallel sequencing to characterize an adenocarcinoma of the tongue, before and after treatment, concludes that complete genomic characterization of a rare tumor has the potential to aid in clinical decision making and identifying therapeutic approaches where no established treatment protocols exist.
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Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition.
Daisuke Ennishi,Katsuyoshi Takata,Wendy Béguelin,Gerben Duns,Anja Mottok,Pedro Farinha,Ali Bashashati,Saeed Saberi,Merrill Boyle,Barbara Meissner,Susana Ben-Neriah,Bruce Woolcock,Adele Telenius,Daniel Lai,Matt Teater,Robert Kridel,Kerry J. Savage,Laurie H. Sehn,Ryan D. Morin,Marco A. Marra,Sohrab P. Shah,Joseph M. Connors,Randy D. Gascoyne,David Scott,Ari Melnick,Christian Steidl +25 more
TL;DR: The paradigmatic restoration of MHC expression by EZH2 inhibitors provides the rationale for synergistic therapies combining immunotherapies with epigenetic reprogramming to enhance tumor recognition and elimination.
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De novo genome sequence assembly of a filamentous fungus using Sanger, 454 and Illumina sequence data.
Scott DiGuistini,Nancy Y. Liao,Darren Platt,Gordon Robertson,Michael Seidel,Simon K. Chan,Roderick T. Docking,Inanc Birol,Robert A. Holt,Martin Hirst,Elaine R. Mardis,Marco A. Marra,Richard C. Hamelin,Jörg Bohlmann,Colette Breuil,Steven J.M. Jones +15 more
TL;DR: A method for assembling draft genome sequences of eukaryotic organisms that integrates sequence information from different sources is reported, and its effectiveness is demonstrated by assembling an approximately 32.5 Mb draft genome sequence for the forest pathogen Grosmannia clavigera, an ascomycete fungus.