M
Marco A. Marra
Researcher at University of British Columbia
Publications - 657
Citations - 215376
Marco A. Marra is an academic researcher from University of British Columbia. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 153, co-authored 620 publications receiving 184684 citations. Previous affiliations of Marco A. Marra include BC Cancer Agency & University of Washington.
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Journal ArticleDOI
Impact of whole genome amplification on analysis of copy number variants
Trevor J. Pugh,Allen Delaney,Noushin Farnoud,Stephane Flibotte,Malachi Griffith,Haiyan I. Li,Hong Qian,Pedro Farinha,Randy D. Gascoyne,Marco A. Marra +9 more
TL;DR: The results suggest WGA material may be appropriate for copy number analysis when amplified samples are compared to similarly amplified samples and that only the CNVs with the greatest significance values detected by such comparisons are likely to be representative of the unamplified samples.
Journal ArticleDOI
A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.
Livia Garzia,Noriyuki Kijima,A. Sorana Morrissy,Pasqualino De Antonellis,Ana Guerreiro-Stucklin,Borja L. Holgado,Xiaochong Wu,Xin Wang,Michael T. Parsons,Kory Zayne,Alex Manno,Claudia M. Kuzan-Fischer,Carolina Nor,Laura K. Donovan,Jessica Liu,Lei Qin,Alexandra Garancher,Kun Wei Liu,Sheila Mansouri,Betty Luu,Yuan Yao Thompson,Vijay Ramaswamy,John Peacock,Hamza Farooq,Patryk Skowron,David Shih,Angela Li,Sherine Ensan,Clinton S. Robbins,Myron I. Cybulsky,Siddhartha Mitra,Yussanne Ma,Richard A. Moore,Andrew J. Mungall,Yoon Jae Cho,William A. Weiss,Jennifer A. Chan,Cynthia Hawkins,Maura Massimino,Nada Jabado,Michal Zapotocky,David Sumerauer,Eric Bouffet,Peter B. Dirks,Uri Tabori,Poul H. Sorensen,Priscilla K. Brastianos,Kenneth Aldape,Steven J.M. Jones,Marco A. Marra,James R. Woodgett,Robert J. Wechsler-Reya,Daniel W. Fults,Michael D. Taylor +53 more
TL;DR: Evidence is presented for medulloblastoma circulating tumor cells (CTCs) in therapy-naive patients and it is demonstrated in vivo, through flank xenografting and parabiosis, that medullOBlastoma CTCs can spread through the blood to the leptomeningeal space to form leptOMeningeal metastases.
Journal ArticleDOI
Cell of origin of transformed follicular lymphoma
Robert Kridel,Anja Mottok,Pedro Farinha,Susana Ben-Neriah,Daisuke Ennishi,Yvonne Zheng,Elizabeth A. Chavez,Hennady P. Shulha,King Tan,Fong Chun Chan,Merrill Boyle,Barbara Meissner,Adele Telenius,Laurie H. Sehn,Laurie H. Sehn,Marco A. Marra,Marco A. Marra,Sohrab P. Shah,Christian Steidl,Joseph M. Connors,Joseph M. Connors,David W. Scott,David W. Scott,Randy D. Gascoyne +23 more
TL;DR: The study demonstrates the existence of molecular heterogeneity in TFL as well as its relationship to the antecedent FL, and shows that composite histology at the time of transformation predicts favorable prognosis.
Journal ArticleDOI
Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells.
TL;DR: A broad view of the effects of the androgen and PKA signaling pathways on the transcriptional program of prostate cancer cells is provided and indicates that only a limited number of genes are targeted by cross-talk between AR and Pka pathways.
Journal ArticleDOI
Hippo Signaling Influences HNF4A and FOXA2 Enhancer Switching during Hepatocyte Differentiation
Olivia Alder,Rebecca L. Cullum,Sam Lee,Arohumam C. Kan,Wei Wei,Yuyin Yi,Victoria C. Garside,Misha Bilenky,Malachi Griffith,A. Sorana Morrissy,Gordon Robertson,Nina Thiessen,Yongjun Zhao,Qian Chen,Duojia Pan,Steven J.M. Jones,Steven J.M. Jones,Steven J.M. Jones,Marco A. Marra,Pamela A. Hoodless +19 more
TL;DR: The data suggest that Hippo signaling may affect hepatocyte differentiation by influencing HNF4A and FOXA2 interactions with temporal enhancers, which is an important consideration for researchers studying cancer biology or mammalian development and/or using transformed cell lines.