M
Marijke J. van Baren
Researcher at Erasmus University Rotterdam
Publications - 9
Citations - 3274
Marijke J. van Baren is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Preaxial polydactyly & Mutation. The author has an hindex of 7, co-authored 7 publications receiving 3067 citations.
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Journal ArticleDOI
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
Vincenzo Bonifati,Vincenzo Bonifati,Patrizia Rizzu,Marijke J. van Baren,Onno Schaap,Guido J. Breedveld,Elmar Krieger,Marieke C. J. Dekker,Ferdinando Squitieri,Pablo Ibanez,Marijke Joosse,Jeroen W.F. van Dongen,Nicola Vanacore,Nicola Vanacore,John C. van Swieten,Alexis Brice,Giuseppe Meco,Cornelia M. van Duijn,Ben A. Oostra,Peter Heutink +19 more
TL;DR: It is shown that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism, and these findings indicate that loss ofDJ-1 function leads to neurodegeneration.
Journal ArticleDOI
Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly.
Laura A. Lettice,Taizo Horikoshi,Simon J. H. Heaney,Marijke J. van Baren,Herma C. van der Linde,Guido J. Breedveld,Marijke Joosse,Nurten A. Akarsu,Ben A. Oostra,Naoto Endo,Minoru Shibata,Mikio Suzuki,Ei-ichi Takahashi,Toshikatsu Shinka,Yutaka Nakahori,Dai Ayusawa,Kazuhiko Nakabayashi,Stephen W. Scherer,Peter Heutink,Robert E. Hill,Sumihare Noji +20 more
TL;DR: A translocation breakpoint in a PPD patient and a transgenic insertion site in the polydactylous mouse mutant sasquatch reveals that the Lmbr1 gene is incidental to the phenotype and that the mutation directly interrupts a cis-acting regulator of Shh, most likely the target for generating PPD mutations in human.
Journal ArticleDOI
A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36.
Henk C. Heus,Anne Hing,Marijke J. van Baren,Marijke Joosse,Guido J. Breedveld,J. C. Wang,Andrea K. Burgess,Helen Donnis-Keller,Cathleen Berglund,J. Zguricas,Stephen W. Scherer,Johanna M. Rommens,Ben A. Oostra,Peter Heutink +13 more
TL;DR: A detailed physical map of the preaxial polydactyly candidate region is constructed and the homeobox gene HLXB9, a putative receptor C7orf2, and two transcripts of unknown function map in the refined candidate region.
Journal ArticleDOI
The PCR Suite
TL;DR: The web application PCR Suite is an extension of the primer design program Primer3 that allows the design of primer sets encompassing single nucleotide polymorphisms, all exons of a single gene, all open reading frames in a list of cDNAs or the creation of overlapping PCR products.
Journal ArticleDOI
A double RING-H2 domain in RNF32, a gene expressed during sperm formation.
Marijke J. van Baren,Herma C. van der Linde,Guido J. Breedveld,Willy M. Baarends,Patrizia Rizzu,Esther de Graaff,Ben A. Oostra,Peter Heutink +7 more
TL;DR: The RING domain is a cysteine-rich zinc-binding motif, which is found in a wide variety of proteins, among which are several proto-oncogenes and the gene implicated in autosomal recessive juvenile parkinsonism, Parkin.