M
Marisol Vieites
Researcher at University of the Republic
Publications - 23
Citations - 1148
Marisol Vieites is an academic researcher from University of the Republic. The author has contributed to research in topics: Trypanosoma cruzi & Salicylaldehyde. The author has an hindex of 18, co-authored 23 publications receiving 1065 citations.
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Journal ArticleDOI
Palladium(II) complexes of 2-benzoylpyridine-derived thiosemicarbazones: spectral characterization, structural studies and cytotoxic activity.
Anayive P. Rebolledo,Marisol Vieites,Dinorah Gambino,Oscar E. Piro,Eduardo E. Castellano,Carlos L. Zani,Elaine Maria de Souza-Fagundes,Letícia R. Teixeira,Alzir A. Batista,Heloisa Beraldo +9 more
TL;DR: All complexes show a quite similar planar fourfold environment around palladium(II).
Journal ArticleDOI
Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets.
Lucía Otero,Marisol Vieites,Lucía Boiani,Ana Denicola,Carolina Rigol,Lucía Opazo,Claudio Olea-Azar,Juan Diego Maya,Antonio Morello,R Luise Krauth-Siegel,Oscar E. Piro,Eduardo E. Castellano,Mercedes González,Dinorah Gambino,Hugo Cerecetto +14 more
TL;DR: Although the complexes showed strong DNA binding, all data strongly suggest that the main trypanocidal mechanism of action is the production of oxidative stress as a result of their bioreduction and extensive redox cycling.
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Vanadium(V) complexes with salicylaldehyde semicarbazone derivatives bearing in vitro anti-tumor activity toward kidney tumor cells (TK-10): crystal structure of [VVO2(5-bromosalicylaldehyde semicarbazone)].
Pabla Noblía,Marisol Vieites,Beatriz S. Parajón-Costa,E. J. Baran,Hugo Cerecetto,Patricia Draper,Mercedes González,Oscar E. Piro,Eduardo E. Castellano,Amaia Azqueta,Adela López de Cerain,Antonio Monge-Vega,Dinorah Gambino +12 more
TL;DR: Results showed that structural modifications on the semicarbazone moiety could have a significant effect on the anti-tumor activity of the vanadium complexes, and no apparent correlation could be demonstrated between reduction potentials of the complexes and their anti-Tumor activities.
Journal ArticleDOI
Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma cruzi activity.
Marisol Vieites,Lucía Otero,Diego Santos,Claudio Olea-Azar,Ester Norambuena,Gabriela Aguirre,Hugo Cerecetto,Mercedes González,Ulrike Kemmerling,Antonio Morello,Juan Diego Maya,Dinorah Gambino +11 more
TL;DR: Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated, showing that some of the compounds could act as dual inhibitors in the parasite, through production of toxic free radicals and interaction with DNA.
Journal ArticleDOI
Improving anti-trypanosomal activity of 3-aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives by complexation with vanadium
Carolina Urquiola,Marisol Vieites,Gabriela Aguirre,A. Marin,Beatriz Solano,Gabriel Arrambide,Pabla Noblía,María Laura Lavaggi,María H. Torre,Mercedes González,Antonio Monge,Dinorah Gambino,Hugo Cerecetto +12 more
TL;DR: The anti-trypanosomal activity of these vanadium complexes could be explained on the basis of their lipophilicity and the electronic characteristics of the quinoxaline substituents.