M
Mark A. Mintun
Researcher at Washington University in St. Louis
Publications - 246
Citations - 50518
Mark A. Mintun is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Positron emission tomography & Alzheimer's disease. The author has an hindex of 91, co-authored 230 publications receiving 47308 citations. Previous affiliations of Mark A. Mintun include University of Kansas & University of Pittsburgh.
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Improved assessment of significant activation in functional magnetic resonance imaging (fMRI) : use of a cluster-size threshold
Steven D. Forman,Jonathan D. Cohen,Mark Fitzgerald,William F. Eddy,Mark A. Mintun,Douglas C. Noll +5 more
TL;DR: In this article, an alternative approach, which relies on the assumption that areas of true neural activity will tend to stimulate signal changes over contiguous pixels, is presented, which can improve statistical power by as much as fivefold over techniques that rely solely on adjusting per pixel false positive probabilities.
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Positron emission tomographic studies of the cortical anatomy of single-word processing
TL;DR: The use of positron emission tomography to measure regional changes in average blood flow during processing of individual auditory and visual words provides support for multiple, parallel routes between localized sensory-specific, phonological, articulatory and semantic-coding areas.
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Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory
Randy L. Buckner,Abraham Z. Snyder,Benjamin J. Shannon,Gina N. LaRossa,Rimmon Sachs,Anthony F. Fotenos,Yvette I. Sheline,William E. Klunk,Chester A. Mathis,John C. Morris,Mark A. Mintun +10 more
TL;DR: One possibility is that lifetime cerebral metabolism associated with regionally specific default activity predisposes cortical regions to AD-related changes, including amyloid deposition, metabolic disruption, and atrophy, which may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment.
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Consensus nomenclature for in vivo imaging of reversibly binding radioligands
Robert B. Innis,Vincent J. Cunningham,Jacques Delforge,Masahiro Fujita,Albert Gjedde,Roger N. Gunn,James E. Holden,Sylvain Houle,Sung-Cheng Huang,Masanori Ichise,Hidehiro Iida,Hiroshi Ito,Yuichi Kimura,Robert A. Koeppe,Gitte M. Knudsen,Juhani Knuuti,Adriaan A. Lammertsma,Marc Laruelle,Jean Logan,Ralph Paul Maguire,Mark A. Mintun,Evan D. Morris,Ramin V. Parsey,Julie C. Price,Mark Slifstein,Vesna Sossi,Tetsuya Suhara,John R. Votaw,Dean F. Wong,Richard E. Carson +29 more
TL;DR: An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands.
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Nonoxidative glucose consumption during focal physiologic neural activity
TL;DR: Transient increases in neural activity cause a tissue uptake of glucose in excess of that consumed by oxidative metabolism, acutely consume much less energy than previously believed, and regulate local blood flow for purposes other than oxidative metabolism.