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Mark J. Ponsford
Researcher at Cardiff University
Publications - 49
Citations - 988
Mark J. Ponsford is an academic researcher from Cardiff University. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 12, co-authored 40 publications receiving 571 citations. Previous affiliations of Mark J. Ponsford include University Hospital of Wales & John Radcliffe Hospital.
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Journal ArticleDOI
Sequestration and Microvascular Congestion Are Associated With Coma in Human Cerebral Malaria
Mark J. Ponsford,Isabelle M. Medana,Panote Prapansilp,Panote Prapansilp,Tran Tinh Hien,Sue J. Lee,Arjen M. Dondorp,Margaret M. Esiri,Nicholas P. J. Day,Nicholas J. White,Gareth D. H. Turner,Gareth D. H. Turner +11 more
TL;DR: Clinopathological correlation showed that sequestration and congestion were significantly associated with deeper levels of premortem coma and shorter time to death in patients with cerebral malaria, and microvascular congestion and sequestration were highly correlated as microscopic findings but were independent predictors of a clinical diagnosis of CM.
Journal ArticleDOI
Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans
Paul Tuijnenburg,Hana Lango Allen,Hana Lango Allen,Siobhan O. Burns,Daniel Greene,Daniel Greene,Machiel H. Jansen,Emily Staples,Jonathan Stephens,Jonathan Stephens,Keren J. Carss,Keren J. Carss,Daniele Biasci,Helen Baxendale,Moira Thomas,Anita Chandra,Sorena Kiani-Alikhan,Hilary Longhurst,Suranjith L. Seneviratne,Eric Oksenhendler,Ilenia Simeoni,Godelieve J. de Bree,Anton T.J. Tool,Ester M. M. van Leeuwen,Eduard H T M Ebberink,Alexander B. Meijer,Salih Tuna,Salih Tuna,Deborah Whitehorn,Deborah Whitehorn,Matthew A. Brown,Matthew A. Brown,Ernest Turro,Ernest Turro,Adrian J. Thrasher,Kenneth G. C. Smith,James Ed Thaventhiran,Taco W. Kuijpers,Zoe Adhya,Hana Alachkar,Ariharan Anantharachagan,Richard Antrobus,Gururaj Arumugakani,Chiara Bacchelli,Claire Bethune,Shahnaz Bibi,Barbara Boardman,Claire Booth,Michael J. Browning,Mary Brownlie,Siobhan Burns,Hayley Clifford,Nichola Cooper,Sophie Davies,John Dempster,Lisa Devlin,Rainer Doffinger,Elizabeth Drewe,David Edgar,William Egner,Tariq El-Shanawany,Bobby Gaspar,Rohit Ghurye,Kimberley Gilmour,Sarah Goddard,Pavel Gordins,Sofia Grigoriadou,Scott Hackett,Rosie Hague,Lorraine Harper,Grant Hayman,A Herwadkar,Stephen M. Hughes,Aarnoud Huissoon,Stephen Jolles,Julie Jones,Peter Kelleher,Nigel Klein,Taco W. Kuijpers,Dinakantha S. Kumararatne,James Laffan,Sara Lear,Hilary Longhurst,Lorena Lorenzo,Jesmeen Maimaris,Ania Manson,Elizabeth M. McDermott,Hazel Millar,Anoop Mistry,Valerie Morrisson,Sai Murng,Iman Nasir,Sergey Nejentsev,Sadia Noorani,Mark J. Ponsford,Waseem Qasim,Ellen Quinn,Isabella Quinti,Alex G. Richter,Crina Samarghitean,Ravishankar Sargur,Sinisa Savic,Suranjith L. Seneviratne,Carrock Sewall,Fiona Shackley,Hans J. Stauss,Cathal Laurence Steele,James Thaventhiran,Adrian J. Thrasher,Steve Welch,Lisa C. Willcocks,Sarita Workman,Austen Worth,Nigel Yeatman,Patrick F.K. Yong,Sofie Ashford,John Bradley,Debra Fletcher,Tracey Hammerton,Roger James,Nathalie Kingston,Willem H. Ouwehand,Christopher J. Penkett,F. Lucy Raymond,Kathleen Stirrups,Marijke Veltman,Tim Young,Naomi Clements-Brod,John Davis,Eleanor Dewhurst,Marie Erwood,Amy Frary,Rachel Linger,Jennifer M. Martin,Sofia Papadia,Karola Rehnstrom,William J. Astle,Antony P. Attwood,Marta Bleda,Keren J. Carss,Louise C. Daugherty,Sri V V Deevi,Stefan Gräf,Csaba Halmagyi,Matthias Haimel,Fengyuan Hu,Vera Matser,Stuart Meacham,Karyn Megy,Olga Shamardina,Catherine Titterton,Ping Yu,Julie von Ziegenweldt,Abigail Furnell,Rutendo Mapeta,Simon Staines,Paula Rayner-Matthews,Christopher Watt +157 more
TL;DR: It is shown that heterozygous loss‐of‐function variants in NFKB1 are the most common known monogenic cause of CVID, which results in a temporally progressive defect in the formation of immunoglobulin‐producing B cells.
Journal ArticleDOI
Cardiometabolic Traits, Sepsis, and Severe COVID-19: A Mendelian Randomization Investigation.
Mark J. Ponsford,Apostolos Gkatzionis,Venexia M Walker,Venexia M Walker,Andrew J. Grant,Robyn E Wootton,Luke S. P. Moore,Luke S. P. Moore,Luke S. P. Moore,Segun Fatumo,Amy M. Mason,Amy M. Mason,Verena Zuber,Verena Zuber,Cristen J. Willer,Humaira Rasheed,Humaira Rasheed,Ben Michael Brumpton,Ben Michael Brumpton,Kristian Hveem,Jan Kristian Damås,Neil M Davies,Neil M Davies,Bjørn Olav Åsvold,Erik Solligård,Simon Jones,Stephen Burgess,Tormod Rogne,Dipender Gill +28 more
Journal ArticleDOI
Clozapine is associated with secondary antibody deficiency
Mark J. Ponsford,Daniel Castle,Tayyeb A. Tahir,Rebecca Robinson,Wendy Wade,Rachael Steven,Kathryn Bramhall,Mo Moody,Emily Carne,Catherine Ford,Daniel Farewell,Paul Williams,Tariq El-Shanawany,Stephen Jolles +13 more
TL;DR: Clozapine use was associated with significantly reduced immunoglobulin levels and an increased proportion of patients using more than five antibiotic courses in a year, which may represent a mechanistic explanation and modifiable risk factor for the increased rates of pneumonia and sepsis-related mortality previously reported in this vulnerable cohort.
Journal ArticleDOI
Are we underestimating seroprevalence of SARS-CoV-2?
TL;DR: Current antibody tests fail to identify people who had mild infections, according to a new study published in the British Journal of Clinical Pathology.