D
David Edgar
Researcher at Trinity College, Dublin
Publications - 7
Citations - 608
David Edgar is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Common variable immunodeficiency & Asymptomatic carrier. The author has an hindex of 5, co-authored 7 publications receiving 351 citations. Previous affiliations of David Edgar include Belfast Health and Social Care Trust.
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Journal ArticleDOI
The European Society for Immunodeficiencies (ESID) Registry Working Definitions for the Clinical Diagnosis of Inborn Errors of Immunity
Markus G. Seidel,Gerhard Kindle,Benjamin Gathmann,Isabella Quinti,Matthew Buckland,Joris M. van Montfrans,Raphael Scheible,Stephan Rusch,Lukas M. Gasteiger,Bodo Grimbacher,Nizar Mahlaoui,Stephan Ehl,Mario Abinun,Michael H. Albert,Sarah Beaussant Cohen,Jacinta Bustamante,Andrew J. Cant,Jean-Laurent Casanova,Helen Chapel,Geneviève de Saint Basile,Esther de Vries,Inderjeet Dokal,Jean Donadieu,Anne Durandy,David Edgar,Teresa Espanol,Amos Etzioni,Alain Fischer,Bobby Gaspar,Richard Gatti,Andrew R. Gennery,Sofia Grigoriadou,Steven M. Holland,Gritta Janka,Maria Kanariou,Christoph Klein,Helen J. Lachmann,Desa Lilic,Ania Manson,Natalia Martinez,Isabelle Meyts,Nicolette Moes,Despina Moshous,Bénédicte Neven,Hans D. Ochs,Capucine Picard,Ellen D. Renner,Frédéric Rieux-Laucat,Reinhard Seger,Annarosa Soresina,Dominique Stoppa-Lyonnet,Vojtech Thon,Adrian J. Thrasher,Frank L. van de Veerdonk,Anna Villa,Corry M.R. Weemaes,Klaus Warnatz,Beata Wolska,Shen-Yin Zhang +58 more
TL;DR: Clinical criteria for a large number of IEI that were designed in expert panels with an external review are presented and implemented for novel entries and verification of existing data sets from 2014, yielding a substantial refinement.
Journal ArticleDOI
Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans
Paul Tuijnenburg,Hana Lango Allen,Hana Lango Allen,Siobhan O. Burns,Daniel Greene,Daniel Greene,Machiel H. Jansen,Emily Staples,Jonathan Stephens,Jonathan Stephens,Keren J. Carss,Keren J. Carss,Daniele Biasci,Helen Baxendale,Moira Thomas,Anita Chandra,Sorena Kiani-Alikhan,Hilary Longhurst,Suranjith L. Seneviratne,Eric Oksenhendler,Ilenia Simeoni,Godelieve J. de Bree,Anton T.J. Tool,Ester M. M. van Leeuwen,Eduard H T M Ebberink,Alexander B. Meijer,Salih Tuna,Salih Tuna,Deborah Whitehorn,Deborah Whitehorn,Matthew A. Brown,Matthew A. Brown,Ernest Turro,Ernest Turro,Adrian J. Thrasher,Kenneth G. C. Smith,James Ed Thaventhiran,Taco W. Kuijpers,Zoe Adhya,Hana Alachkar,Ariharan Anantharachagan,Richard Antrobus,Gururaj Arumugakani,Chiara Bacchelli,Claire Bethune,Shahnaz Bibi,Barbara Boardman,Claire Booth,Michael J. Browning,Mary Brownlie,Siobhan Burns,Hayley Clifford,Nichola Cooper,Sophie Davies,John Dempster,Lisa Devlin,Rainer Doffinger,Elizabeth Drewe,David Edgar,William Egner,Tariq El-Shanawany,Bobby Gaspar,Rohit Ghurye,Kimberley Gilmour,Sarah Goddard,Pavel Gordins,Sofia Grigoriadou,Scott Hackett,Rosie Hague,Lorraine Harper,Grant Hayman,A Herwadkar,Stephen M. Hughes,Aarnoud Huissoon,Stephen Jolles,Julie Jones,Peter Kelleher,Nigel Klein,Taco W. Kuijpers,Dinakantha S. Kumararatne,James Laffan,Sara Lear,Hilary Longhurst,Lorena Lorenzo,Jesmeen Maimaris,Ania Manson,Elizabeth M. McDermott,Hazel Millar,Anoop Mistry,Valerie Morrisson,Sai Murng,Iman Nasir,Sergey Nejentsev,Sadia Noorani,Mark J. Ponsford,Waseem Qasim,Ellen Quinn,Isabella Quinti,Alex G. Richter,Crina Samarghitean,Ravishankar Sargur,Sinisa Savic,Suranjith L. Seneviratne,Carrock Sewall,Fiona Shackley,Hans J. Stauss,Cathal Laurence Steele,James Thaventhiran,Adrian J. Thrasher,Steve Welch,Lisa C. Willcocks,Sarita Workman,Austen Worth,Nigel Yeatman,Patrick F.K. Yong,Sofie Ashford,John Bradley,Debra Fletcher,Tracey Hammerton,Roger James,Nathalie Kingston,Willem H. Ouwehand,Christopher J. Penkett,F. Lucy Raymond,Kathleen Stirrups,Marijke Veltman,Tim Young,Naomi Clements-Brod,John Davis,Eleanor Dewhurst,Marie Erwood,Amy Frary,Rachel Linger,Jennifer M. Martin,Sofia Papadia,Karola Rehnstrom,William J. Astle,Antony P. Attwood,Marta Bleda,Keren J. Carss,Louise C. Daugherty,Sri V V Deevi,Stefan Gräf,Csaba Halmagyi,Matthias Haimel,Fengyuan Hu,Vera Matser,Stuart Meacham,Karyn Megy,Olga Shamardina,Catherine Titterton,Ping Yu,Julie von Ziegenweldt,Abigail Furnell,Rutendo Mapeta,Simon Staines,Paula Rayner-Matthews,Christopher Watt +157 more
TL;DR: It is shown that heterozygous loss‐of‐function variants in NFKB1 are the most common known monogenic cause of CVID, which results in a temporally progressive defect in the formation of immunoglobulin‐producing B cells.
Journal ArticleDOI
Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations.
Julian Thalhammer,Gerhard Kindle,Alexandra Nieters,Stephan Rusch,Mikko Seppänen,Alain Fischer,Bodo Grimbacher,David Edgar,Matthew Buckland,Matthew Buckland,Nizar Mahlaoui,Stephan Ehl,Kaan Boztug,Juergen Brunner,Ulrike F. Demel,Elisabeth Förster-Waldl,Lukas M. Gasteiger,Lisa Göschl,Marina Kojić,Andrea Schroll,Markus G. Seidel,Uwe Wintergerst,Lukas Wisgrill,Svetlana O. Sharapova,Jean-Christophe Goffard,Tessa Kerre,Isabelle Meyts,Fine Roosens,Julie Smet,Filomeen Haerynck,Zelimir Pavle Eric,Veneta Milenova,Alenka Gagro,Darko Richter,Zita Chovancová,Eva Hlaváčková,Jiri Litzman,Tomas Milota,Anna Sediva,Dalia Abd Elaziz,Radwa Alkady,Rabab El Hawary,Alia Eldash,Nermeen Galal,Sohilla Lotfy,Safa Meshaal,Shereen M. Reda,Ali Sobh,Aisha Elmarsafy,Pauline Brosselin,Virginie Courteille,Nathalie de Vergnes,Sven Kracker,Martine Pergent,Philippe Randrianomenjanahary,Gerrit Ahrenstorf,Michael H. Albert,Tobias Ankermann,Faranaz Atschekzei,Ulrich Baumann,Benjamin Becker,Uta Behrends,Bernd H. Belohradsky,Anika-Kerstin Biegner,Nadine Binder,Sebastian F. N. Bode,Christoph Boesecke,Benedikt Boetticher,Michael Borte,Stephan Borte,Carl Friedrich Classen,Johannes Dirks,Gregor Dückers,Sabine M El-Helou,Diana Ernst,Maria Fasshauer,Gisela Fecker,Kerstin Felgentreff,Dirk Foell,Sujal Ghosh,Hermann J. Girschick,Sigune Goldacker,Norbert Graf,Dagmar Graf,Johann Greil,Leif G. Hanitsch,Fabian Hauck,Maximilian Heeg,Sabine Heine,Joerg C. Henes,Manfred Hoenig,Ursula Holzer,Dirk Holzinger,Gerd Horneff,Patrick Hundsdoerfer,Alexandra Jablonka,Donate Jakoby,Oana Joean,Petra Kaiser-Labusch,Christian Klemann,Robin Kobbe,Julia Körholz,Christof M. Kramm,Renate Krüger,Sybille Landwehr-Kenzel,Kai Lehmberg,Johannes G. Liese,Conrad Ferdinand Lippert,Maria Elena Maccari,Katja Masjosthusmann,Andrea Meinhardt,Markus Metzler,Henner Morbach,Ingo Müller,Nora Naumann-Bartsch,Jennifer Neubert,Tim Niehues,Hans-Hartmut Peter,Nikolaus Rieber,Henrike Ritterbusch,Jürgen K. Rockstroh,Joachim Roesler,Uwe Schauer,Raphael Scheible,Marc Schmalzing,Reinhold E. Schmidt,Dominik T. Schneider,Stefan Schreiber,Catharina Schuetz,Ansgar Schulz,Hendrik Schulze-Koops,Ulf Schulze-Sturm,Volker Schuster,Eva C. Schwaneck,Klaus Schwarz,Carolynne Schwarze-Zander,Mehtap Sirin,Alla Skapenko,Georgios Sogkas,Monika Sparber-Sauer,Carsten Speckmann,Sandra Steinmann,Sophie Stiehler,Klaus Tenbrock,Horst von Bernuth,Klaus Warnatz,Jan-Christian Wasmuth,Michael E. Weiss,Torsten Witte,Kirsten Wittke,Helmut Wittkowski,R Zeuner,Evangelia Farmaki,Maria N. Hatzistilianou,Ioannis Kakkas,Maria Kanariou,Androniki Kapousouzi,Emmanouil Liatsis,Paraskevi Maggina,Efimia Papadopoulou-Alataki,Maria Raptaki,Matthaios Speletas,Sofia Tantou,Vera Goda,Gergely Kriván,László Maródi,Hassan Abolhassani,Asghar Aghamohammadi,Nima Rezaei,Conleth Feighery,Timothy Ronan Leahy,Paul Ryan,Nurit Assia Batzir,Ben Zion Garty,Hannah Tamary,Alessandro Aiuti,Donato Amodio,Chiara Azzari,Federica Barzaghi,Lucia Augusta Baselli,Caterina Cancrini,Maria Carrabba,Marco Cazzaniga,Simone Cesaro,Matteo Chinello,Maria Giovanna Danieli,Rosa Maria Dellepiane,Giovanna Fabio,Eleonora Gambineri,Lorenzo Lodi,Vassilios Lougaris,Carolina Marasco,Baldassarre Martire,Antonio Marzollo,Cinzia Milito,Viviana Moschese,Claudio Pignata,Alessandro Plebani,Fulvio Porta,Isabella Quinti,Silvia Ricci,Annarosa Soresina,Alberto Tommasini,Angelo Vacca,Clementina Vanessa,Audra Blažienė,Brigita Sitkauskiene,Ewelina Gowin,Edyta Heropolitańska-Pliszka,Barbara Pietrucha,Anna Szaflarska,Ewa Więsik-Szewczyk,Beata Wolska-Kuśnierz,I. Esteves,Emilia Faria,Laura Hora Marques,João Farela Neves,Susana L. Silva,Carla Teixeira,Sara Pereira da Silva,Brindusa Ruxandra Capilna,Marina N. Guseva,Anna Shcherbina,Anna Bobcakova,Peter Ciznar,Juliana Gabzdilova,Milos Jesenak,Lenka Kapustova,Jaroslava Orosova,Otilia Petrovicova,Stefan Raffac,Peter Kopač,Luis M. Allende,Arnau Antolí,Gemma Rocamora Blanch,Javier Carbone,Romina Dieli-Crimi,Marina Garcia-Prat,Juana Gil-Herrera,Luis Ignacio Gonzalez-Granado,Pilar Llobet Agulló,Peter Olbrich,Alba Parra-Martínez,Estela Paz-Artal,Daniel E Pleguezuelo,Nerea Salmón Rodríguez,Silvia Sánchez-Ramón,Juan Luis Santos-Pérez,Xavier Solanich,Pere Soler-Palacín,Miriam González-Amores,Olov Ekwall,Anders Fasth,Michaela Bitzenhofer-Grüber,Fabio Candotti,Florentia Dimitriou,Ulrich Heininger,Andreas Holbro,Peter Jandus,Antonios G.A. Kolios,Karin Marschall,Jana Pachlopnik Schmid,Klara M. Posfay-Barbe,Seraina Prader,Janine Reichenbach,Urs C. Steiner,Johannes Trück,Robbert G. M. Bredius,Suzanne de Kruijf Bazen,Esther de Vries,Stefanie S. V. Henriet,Taco W. Kuijpers,Judith Potjewijd,Abraham Rutgers,Kim Stol,Koen J. van Aerde,J. Merlijn van den Berg,Annick A. J. M. van de Ven,Jorisvan Montfrans,Sezin Aydemir,Safa Baris,Figen Dogu,Aydan Ikinciogullari,Elif Karakoc-Aydiner,Sara Sebnem Kilic,Ayca Kiykim,Şefika İlknur Kökçü Karadağ,Necil Kutukculer,Suheyla Ocak,Ekrem Unal,Oksana Boyarchuk,Anna Hilfanova,Larysa Kostyuchenko,Hana Alachkar,Peter D. Arkwright,Helen Baxendale,Jolanta Bernatoniene,Tanya I. Coulter,Tomaz Garcez,Sarah Goddard,Mark M. Gompels,Sofia Grigoriadou,Richard Herriot,A Herwadkar,Aarnoud Huissoon,Lisa Ibberson,Zoreh Nademi,Sadia Noorani,Shahnaz Parvin,Cathal Laurence Steele,Moira Thomas,Catherine Waruiru,Patrick F.K. Yong,Helen Bourne +313 more
TL;DR: In this paper, age-related initial presenting manifestations of Inborn errors of immunity (IEI) including different IEI disease cohorts were analyzed. But, although increased infection susceptibility is a well-known initial IEI manifestation, less is known about the frequency of other presenting manifestations.
Journal ArticleDOI
C1 inhibitor deficiency: 2014 United Kingdom consensus document
Hilary Longhurst,M. D. Tarzi,F. Ashworth,Claire Bethune,C. Cale,John Dempster,Mark Gompels,Stephen Jolles,Suranjith L. Seneviratne,Christine Symons,Arthur Price,David Edgar +11 more
TL;DR: An updated 2014 United Kingdom consensus document for the management of C1 inhibitor‐deficient patients, representing a joint venture between the United Kingdom Primary Immunodeficiency Network and Hereditary Angioedema UK is presented.
Journal ArticleDOI
Specific antibody deficiencies in clinical practice
TL;DR: Assessment of immunity and therapeutic actions to deal with SADs need to be based on clinical evidence rather than solely on arbitrarily defined antibody responses.