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Anne Louise Hansen
Researcher at Aarhus University
Publications - 15
Citations - 737
Anne Louise Hansen is an academic researcher from Aarhus University. The author has contributed to research in topics: Interferon & Innate immune system. The author has an hindex of 8, co-authored 15 publications receiving 415 citations.
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Journal ArticleDOI
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
David Olagnier,Ensieh Farahani,Jacob Thyrsted,Julia Blay-Cadanet,Angela Herengt,Manja Idorn,Alon Schneider Hait,Alon Schneider Hait,Bruno Hernáez,Alice Knudsen,Marie B. Iversen,Mirjam Schilling,Sofie E. Jørgensen,Sofie E. Jørgensen,Michelle M. Thomsen,Michelle M. Thomsen,Line S. Reinert,Michael Lappe,Huy-Dung Hoang,Victoria H. Gilchrist,Anne Louise Hansen,Rasmus Ottosen,Camilla G. Nielsen,Charlotte Möller,Demi van der Horst,Suraj Peri,Siddharth Balachandran,Jinrong Huang,Martin R. Jakobsen,Esben B. Svenningsen,Thomas B. Poulsen,Lydia Bartsch,Anne L. Thielke,Yonglun Luo,Tommy Alain,Jan Rehwinkel,Antonio Alcami,John Hiscott,Trine H. Mogensen,Trine H. Mogensen,Søren R. Paludan,Christian K. Holm +41 more
TL;DR: NRF2 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective in limiting virus replication and in suppressing the pro-inflammatory responses of human pathogenic viruses, including SARS-CoV2.
Journal ArticleDOI
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses
Christian K. Holm,Stine H. Rahbek,Hans Henrik Gad,Rasmus O. Bak,Martin R. Jakobsen,Zhaozaho Jiang,Anne Louise Hansen,Simon K. Jensen,Chenglong Sun,Martin K. Thomsen,Anders Laustsen,Camilla G. Nielsen,Kasper Severinsen,Yingluo Xiong,Yingluo Xiong,Dara Burdette,Veit Hornung,Robert Jan Lebbink,Mogens Duch,Katherine A. Fitzgerald,Shervin Bahrami,Jakob Giehm Mikkelsen,Rune Hartmann,Søren R. Paludan +23 more
TL;DR: A STING-dependent, cGAS-independent pathway important for full interferon production and antiviral control of enveloped RNA viruses, including influenza A virus (IAV), which is targeted by IAV is identified.
Journal ArticleDOI
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
David Olagnier,Aske M Brandtoft,Camilla Gunderstofte,Nikolaj L. Villadsen,Christian Krapp,Anne L. Thielke,Anders Laustsen,Suraj Peri,Anne Louise Hansen,Lene Bonefeld,Jacob Thyrsted,Victor Bruun,Marie B. Iversen,Lin Lin,Virginia M. Artegoitia,Chenhe Su,Long Yang,Rongtuan Lin,Siddharth Balachandran,Yonglun Luo,Mette Nyegaard,Bernadette Marrero,Raphaela Goldbach-Mansky,Mona Motwani,Dylan G. Ryan,Katherine A. Fitzgerald,Luke A. J. O'Neill,Anne Kruse Hollensen,Christian Kroun Damgaard,Frank Vincenzo de Paoli,Hanne Christine Bertram,Martin R. Jakobsen,Thomas B. Poulsen,Christian K. Holm +33 more
TL;DR: Nrf2 activation decreases STING expression and responsiveness to STING agonists while increasing susceptibility to infection with DNA viruses, and a link between metabolic reprogramming and antiviral cytosolic DNA sensing in human cells is suggested.
Journal ArticleDOI
T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication.
Randi K. Berg,Stine H. Rahbek,Emil Kofod-Olsen,Christian K. Holm,Jesper Melchjorsen,David G. Jensen,Anne Louise Hansen,Louise B. Jørgensen,Lars Østergaard,Martin Tolstrup,Carsten Schade Larsen,Søren R. Paludan,Martin R. Jakobsen,Trine H. Mogensen +13 more
TL;DR: It is reported that human primary T cells fail to induce strong IFN responses, despite the fact that this cell type does express key molecules involved in DNA signaling pathways, and cytosolic DNA fails to affect HIV replication.
Journal ArticleDOI
STING palmitoylation as a therapeutic target
TL;DR: Two independent studies recently identified pharmacological inhibitors of STING that target STING palmitoylation, a posttranslational modification necessary for STING signaling.