S
Stine H. Rahbek
Researcher at Aarhus University
Publications - 6
Citations - 401
Stine H. Rahbek is an academic researcher from Aarhus University. The author has contributed to research in topics: Innate immune system & Pattern recognition receptor. The author has an hindex of 5, co-authored 6 publications receiving 310 citations.
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Journal ArticleDOI
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses
Christian K. Holm,Stine H. Rahbek,Hans Henrik Gad,Rasmus O. Bak,Martin R. Jakobsen,Zhaozaho Jiang,Anne Louise Hansen,Simon K. Jensen,Chenglong Sun,Martin K. Thomsen,Anders Laustsen,Camilla G. Nielsen,Kasper Severinsen,Yingluo Xiong,Yingluo Xiong,Dara Burdette,Veit Hornung,Robert Jan Lebbink,Mogens Duch,Katherine A. Fitzgerald,Shervin Bahrami,Jakob Giehm Mikkelsen,Rune Hartmann,Søren R. Paludan +23 more
TL;DR: A STING-dependent, cGAS-independent pathway important for full interferon production and antiviral control of enveloped RNA viruses, including influenza A virus (IAV), which is targeted by IAV is identified.
Journal ArticleDOI
HSV Infection Induces Production of ROS, which Potentiate Signaling from Pattern Recognition Receptors: Role for S-glutathionylation of TRAF3 and 6
Regina Gonzalez-Dosal,Kristy A. Horan,Stine H. Rahbek,Hidenori Ichijo,Zhijian J. Chen,John J. Mieyal,John J. Mieyal,Rune Hartmann,Søren R. Paludan +8 more
TL;DR: It is demonstrated that ROS are essential for effective activation of signaling pathways leading to a successful innate immune response against HSV infection.
Journal ArticleDOI
T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication.
Randi K. Berg,Stine H. Rahbek,Emil Kofod-Olsen,Christian K. Holm,Jesper Melchjorsen,David G. Jensen,Anne Louise Hansen,Louise B. Jørgensen,Lars Østergaard,Martin Tolstrup,Carsten Schade Larsen,Søren R. Paludan,Martin R. Jakobsen,Trine H. Mogensen +13 more
TL;DR: It is reported that human primary T cells fail to induce strong IFN responses, despite the fact that this cell type does express key molecules involved in DNA signaling pathways, and cytosolic DNA fails to affect HIV replication.
Journal ArticleDOI
Inflammatory Cytokines Break Down Intrinsic Immunological Tolerance of Human Primary Keratinocytes to Cytosolic DNA
Srikanth Chiliveru,Stine H. Rahbek,Simon K. Jensen,Sofie E. Jørgensen,Sara K. Nissen,Stig Hill Christiansen,Trine H. Mogensen,Trine H. Mogensen,Martin R. Jakobsen,Lars Iversen,Claus Johansen,Søren R. Paludan +11 more
TL;DR: It is reported that human keratinocytes are tolerant to cytoplasmic DNA, and it is suggested that inflammatory environments in the skin can lead to breakdown of tolerance for DNA in keratinocyte which could contribute to the development of inflammatory diseases.
Journal ArticleDOI
Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans.
Alon Schneider Hait,Alon Schneider Hait,David Olagnier,Vanessa Sancho-Shimizu,Kristian Alsbjerg Skipper,Marie Helleberg,Simon Muller Larsen,Chiranjeevi Bodda,Liviu Ionut Moldovan,Fanghui Ren,Nanna-Sophie Brinck Andersen,Nanna-Sophie Brinck Andersen,Michelle M. Thomsen,Michelle M. Thomsen,Mette Ratzer Freytag,Mette Ratzer Freytag,Sathya Darmalinggam,Isobel Parkes,Darshana D. Kadekar,Stine H. Rahbek,Demi van der Horst,Lasse Sommer Kristensen,Kristina Eriksson,Jørgen Kjems,Serge Mostowy,Mette Christiansen,Jacob Giehm Mikkelsen,Christian Brandt,Søren R. Paludan,Søren R. Paludan,Trine H. Mogensen,Trine H. Mogensen +31 more
TL;DR: A previously unknown link between defective autophagy and an inborn error of immunity that can lead to increased susceptibility to HSV2 infection is described, suggesting an important role for autophileagy in antiviral immunity in the CNS.