Martina Gimpfl

TL;DR: It is suggested that a peri-conceptional obesogenic exposure is sufficient to shape offspring gene expression patterns and health outcomes in a sex- and organ-specific manner, indicating varying developmental vulnerabilities between sexes towards metabolic disease in response to maternal overnutrition.

TL;DR: MCK-2 may play a dual role in MCMV infection, as a chemokine regulating the host response and attracting specific target cells and as part of a glycoprotein complex promoting entry into cells crucial for virus dissemination.

TL;DR: Qualitative modification of the fatty acid spectrum of a high-energy maternal diet, using a combination of both MCFAs and n-3 LC-PUFAs, seems to be a promising interventional approach to ameliorate the adipogenic milieu of mice before and during gestation.

TL;DR: It is indicated that sex-specific programming effects of parental obesity already start in the pre-implantation period and specific alterations of the sperm miRNA profile are revealed as mechanistic link to Programming effects of paternal obesity.

TL;DR: This study identifies a suspicious nonsynonymous single nucleotide polymorphism (SNP) in the integrin beta-6 gene (ITGB6G1312A) entailing a V438M substitution and provides a starting point for elucidating integrin αVβ6 function and for understanding a pathomechanistical relevance of ITGB6V438M.