T
Takao Suzuki
Publications - 8
Citations - 734
Takao Suzuki is an academic researcher. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 5, co-authored 8 publications receiving 277 citations.
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Journal ArticleDOI
A cross-population atlas of genetic associations for 220 human phenotypes
Saori Sakaue,Masahiro Kanai,Yosuke Tanigawa,Juha Karjalainen,Mitja I. Kurki,Seizo Koshiba,Akira Narita,Takahiro Konuma,Kenichi Yamamoto,Masato Akiyama,Kazuyoshi Ishigaki,Akari Suzuki,Ken Suzuki,Wataru Obara,Ken Yamaji,Kazuhisa Takahashi,Satoshi Asai,Yasuo Takahashi,Takao Suzuki,Nobuaki Shinozaki,Hiroki Yamaguchi,Shiro Minami,Shigeo Murayama,Kozo Yoshimori,Satoshi Nagayama,Daisuke Obata,Masahiko Higashiyama,Akihide Masumoto,Yukihiro Koretsune,FinnGen,Kaoru Ito,Chikashi Terao,Toshimasa Yamauchi,Issei Komuro,Takashi Kadowaki,Gen Tamiya,Masayuki Yamamoto,Yusuke Nakamura,Yusuke Nakamura,Michiaki Kubo,Yoshinori Murakami,Kazuhiko Yamamoto,Yoichiro Kamatani,Aarno Palotie,Aarno Palotie,Aarno Palotie,Manuel A. Rivas,Mark J. Daly,Koichi Matsuda,Yukinori Okada +49 more
TL;DR: In this paper, the authors conducted 220 deep-phenotype genome-wide association studies (diseases, biomarkers and medication usage) in BioBank Japan (n = 179,000), by incorporating past medical history and text-mining of electronic medical records.
Journal ArticleDOI
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Kazuyoshi Ishigaki,Kazuyoshi Ishigaki,Masato Akiyama,Masahiro Kanai,Masahiro Kanai,Atsushi Takahashi,Eiryo Kawakami,Hiroki Sugishita,Saori Sakaue,Saori Sakaue,Nana Matoba,Siew-Kee Low,Yukinori Okada,Chikashi Terao,Tiffany Amariuta,Tiffany Amariuta,Steven Gazal,Steven Gazal,Yuta Kochi,Momoko Horikoshi,Ken Suzuki,Ken Suzuki,Kaoru Ito,Satoshi Koyama,Kouichi Ozaki,Shumpei Niida,Yasushi Sakata,Yasuhiko Sakata,Takashi Kohno,Kouya Shiraishi,Yukihide Momozawa,Makoto Hirata,Koichi Matsuda,Masashi Ikeda,Nakao Iwata,Shiro Ikegawa,Ikuyo Kou,Toshihiro Tanaka,Hidewaki Nakagawa,Akari Suzuki,Tomomitsu Hirota,Mayumi Tamari,Kazuaki Chayama,Daiki Miki,Masaki Mori,Satoshi Nagayama,Yataro Daigo,Yataro Daigo,Yoshio Miki,Toyomasa Katagiri,Osamu Ogawa,Wataru Obara,Hidemi Ito,Teruhiko Yoshida,Issei Imoto,Takashi Takahashi,Chizu Tanikawa,Takao Suzuki,Nobuaki Sinozaki,Shiro Minami,Hiroki Yamaguchi,Satoshi Asai,Yasuo Takahashi,Ken Yamaji,Kazuhisa Takahashi,Tomoaki Fujioka,Ryo Takata,Hideki Yanai,Akihide Masumoto,Yukihiro Koretsune,Hiromu Kutsumi,Masahiko Higashiyama,Shigeo Murayama,Naoko Minegishi,Kichiya Suzuki,Kozo Tanno,Atsushi Shimizu,Taiki Yamaji,Motoki Iwasaki,Norie Sawada,Hirokazu Uemura,Hirokazu Uemura,Keitaro Tanaka,Mariko Naito,Mariko Naito,Makoto Sasaki,Kenji Wakai,Shoichiro Tsugane,Masayuki Yamamoto,Kazuhiko Yamamoto,Yoshinori Murakami,Yusuke Nakamura,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Johji Inazawa,Toshimasa Yamauchi,Takashi Kadowaki,Michiaki Kubo,Yoichiro Kamatani +99 more
TL;DR: A large-scale genome-wide association study in a Japanese population provides insights into the etiology of complex diseases and highlights the importance of performing GWAS in non-European populations.
Journal ArticleDOI
Association of VKORC1 and CYP2C9 polymorphisms with warfarin dose requirements in Japanese patients
Taisei Mushiroda,Yozo Ohnishi,Susumu Saito,Atsushi Takahashi,Yuka Kikuchi,Shigeru Saito,Hideki Shimomura,Yasuhiko Wanibuchi,Takao Suzuki,Naoyuki Kamatani,Yusuke Nakamura +10 more
TL;DR: Analysis of the combination of VKORC1 and CYP2C9 genotypes should identify warfarin-sensitive patients who require a lower dose of drug, allowing personalized warfarIn treatment.
Journal ArticleDOI
High-resolution SNP and haplotype maps of the human gamma-glutamyl carboxylase gene (GGCX) and association study between polymorphisms in GGCX and the warfarin maintenance dose requirement of the Japanese population.
Pei-Chieng Cha,Taisei Mushiroda,Atsushi Takahashi,Shigeru Saito,Hideki Shimomura,Takao Suzuki,Naoyuki Kamatani,Yusuke Nakamura +7 more
TL;DR: A high-resolution single nucleotide polymorphism (SNP) and haplotype maps of an 18-kb genomic region corresponding to the GGCX locus in the Japanese population are reported to provide a useful resource for further elucidating this association.
Posted ContentDOI
A global atlas of genetic associations of 220 deep phenotypes
Saori Sakaue,Masahiro Kanai,Yosuke Tanigawa,Juha Karjalainen,Mitja I. Kurki,Seizo Koshiba,Akira Narita,Takahiro Konuma,Kenichi Yamamoto,Masato Akiyama,Kazuyoshi Ishigaki,Akari Suzuki,Ken Suzuki,Wataru Obara,Ken Yamaji,Kazuhisa Takahashi,Satoshi Asai,Yasuo Takahashi,Takao Suzuki,Nobuaki Shinozaki,Hiroki Yamaguchi,Shiro Minami,Shigeo Murayama,Kozo Yoshimori,Satoshi Nagayama,Daisuke Obata,Masahiko Higashiyama,Akihide Masumoto,Yukihiro Koretsune,Finn Gen,Kaoru Ito,Chikashi Terao,Toshimasa Yamauchi,Issei Komuro,Takashi Kadowaki,Gen Tamiya,Masayuki Yamamoto,Yusuke Nakamura,Yusuke Nakamura,Michiaki Kubo,Yoshinori Murakami,Kazuhiko Yamamoto,Yoichiro Kamatani,Aarno Palotie,Aarno Palotie,Aarno Palotie,Manuel A. Rivas,Mark J. Daly,Koichi Matsuda,Yukinori Okada +49 more
TL;DR: This study conducted 220 deep-phenotype GWASs in BioBank Japan, and performed statistical decomposition of matrices of phenome-wide summary statistics, and identified the latent genetic components, which pinpointed the responsible variants and shared biological mechanisms underlying current disease classifications across populations.