F
FinnGen
Researcher at University of Helsinki
Publications - 26
Citations - 994
FinnGen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Genome-wide association study & Biobank. The author has an hindex of 7, co-authored 26 publications receiving 248 citations.
Papers
More filters
Journal ArticleDOI
A cross-population atlas of genetic associations for 220 human phenotypes
Saori Sakaue,Masahiro Kanai,Yosuke Tanigawa,Juha Karjalainen,Mitja I. Kurki,Seizo Koshiba,Akira Narita,Takahiro Konuma,Kenichi Yamamoto,Masato Akiyama,Kazuyoshi Ishigaki,Akari Suzuki,Ken Suzuki,Wataru Obara,Ken Yamaji,Kazuhisa Takahashi,Satoshi Asai,Yasuo Takahashi,Takao Suzuki,Nobuaki Shinozaki,Hiroki Yamaguchi,Shiro Minami,Shigeo Murayama,Kozo Yoshimori,Satoshi Nagayama,Daisuke Obata,Masahiko Higashiyama,Akihide Masumoto,Yukihiro Koretsune,FinnGen,Kaoru Ito,Chikashi Terao,Toshimasa Yamauchi,Issei Komuro,Takashi Kadowaki,Gen Tamiya,Masayuki Yamamoto,Yusuke Nakamura,Yusuke Nakamura,Michiaki Kubo,Yoshinori Murakami,Kazuhiko Yamamoto,Yoichiro Kamatani,Aarno Palotie,Aarno Palotie,Aarno Palotie,Manuel A. Rivas,Mark J. Daly,Koichi Matsuda,Yukinori Okada +49 more
TL;DR: In this paper, the authors conducted 220 deep-phenotype genome-wide association studies (diseases, biomarkers and medication usage) in BioBank Japan (n = 179,000), by incorporating past medical history and text-mining of electronic medical records.
Journal ArticleDOI
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers.
Nina Mars,Jukka Koskela,Pietari Ripatti,Tuomo Kiiskinen,Aki S. Havulinna,Aki S. Havulinna,Joni V Lindbohm,Ari Ahola-Olli,Mitja I. Kurki,Mitja I. Kurki,Mitja I. Kurki,Juha Karjalainen,Juha Karjalainen,Juha Karjalainen,Priit Palta,Priit Palta,FinnGen,Benjamin M. Neale,Benjamin M. Neale,Mark J. Daly,Mark J. Daly,Veikko Salomaa,Aarno Palotie,Aarno Palotie,Aarno Palotie,Elisabeth Widen,Samuli Ripatti,Samuli Ripatti +27 more
TL;DR: In a large and prospective cohort, higher polygenic risk is associated with higher risk and earlier age of onset for cardiometabolic disorders and cancer, and has added value to clinical risk scores in clinical disease prediction.
Journal ArticleDOI
Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan.
Saori Sakaue,Saori Sakaue,Masahiro Kanai,Juha Karjalainen,Masato Akiyama,Mitja I. Kurki,Nana Matoba,Atsushi Takahashi,Makoto Hirata,Michiaki Kubo,Koichi Matsuda,Yoshinori Murakami,FinnGen,Mark J. Daly,Yoichiro Kamatani,Yukinori Okada +15 more
TL;DR: Cross-biobank analysis reveals that polygenic risk scores (PRS) for hypertension and obesity are associated with shorter lifespan, serving as a proof-of-principle that PRS could pinpoint causal risk factors that affect long-term health outcomes.
Journal ArticleDOI
Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health.
Satu Strausz,Sanni Ruotsalainen,Hanna Ollila,Juha Karjalainen,Juha Karjalainen,Juha Karjalainen,Tuomo Kiiskinen,Tuomo Kiiskinen,Mary Pat Reeve,Mitja I. Kurki,Mitja I. Kurki,Mitja I. Kurki,Nina Mars,Aki S. Havulinna,Aki S. Havulinna,Elina Luonsi,Dina Mansour Aly,Emma Ahlqvist,Maris Teder-Laving,Priit Palta,Priit Palta,Leif Groop,Leif Groop,Reedik Mägi,Antti Mäkitie,Veikko Salomaa,Adel Bachour,Tiinamaija Tuomi,FinnGen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Tuula Palotie,Samuli Ripatti,Samuli Ripatti +34 more
TL;DR: The causal link between obesity and OSA, and the joint genetic basis between OSA and comorbidities, are supported, and evidence for non-BMI-dependent effects is provided.
Posted ContentDOI
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
Tomoko Nakanishi,Sara Pigazzini,Frauke Degenhardt,Mattia Cordioli,Guillaume Butler-Laporte,Douglas Maya-Miles,Beatriz Nafr_a-Jim_nez,Youssef Bouysran,Mari Niemi,Adriana Palom,David Ellinghaus,Atlas Khan,Manuel Mart_nez-Bueno,Selina Rolker,Sara Amitano,Luisa Roade,FinnGen,Francesca Fava,Christoph D. Spinner,Daniele Prati,David Bernardo,Federico García,Gilles Darcis,Israel Fern_ndez-Cadenas,Jan Cato Holter,Jesus M. Banales,Robert Frithiof,Krzysztof Kiryluk,Stefano Duga,Rosanna Asselta,Alexandre C. Pereira,Manuel Romero-G_mez,Luis Bujanda,Johannes R. Hov,Isabelle Migeotte,Alessandra Renieri,Anna M. Planas,Kerstin U. Ludwig,Maria Buti,Souad Rahmouni,Marta E. Alarc_n-Riquelme,Eva C. Schulte,Andre Franke,Tom H. Karlsen,Luca Valenti,Hugo Zeberg,J. Brent Richards,Andrea Ganna +47 more
TL;DR: In this article, the authors characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium.