M
Masamichi Takami
Researcher at Showa University
Publications - 108
Citations - 5406
Masamichi Takami is an academic researcher from Showa University. The author has contributed to research in topics: Osteoclast & RANKL. The author has an hindex of 31, co-authored 103 publications receiving 4978 citations. Previous affiliations of Masamichi Takami include Nippon Steel & Tokyo Institute of Technology.
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Journal ArticleDOI
Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblasts.
Masamichi Takami,Naoyuki Takahashi,Nobuyuki Udagawa,Chisato Miyaura,K Suda,Je-Tae Woo,Thomas J. Martin,Kazuo Nagai,Tatsuo Suda +8 more
TL;DR: It is reported that intracellular calcium-elevating compounds such as ionomycin, cyclopiazonic acid, and thapsigargin induced osteoclast formation in cocultures of mouse bone marrow cells and primary osteoblasts and treatment with these compounds stimulated the expression of both RANKL and OPG messenger RNAs (mRNAs).
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Disabling of Receptor Activator of Nuclear Factor-κB (RANK) Receptor Complex by Novel Osteoprotegerin-like Peptidomimetics Restores Bone Loss in Vivo
TL;DR: Features of a rationally designed small molecule mimic of osteoprotegerin suggest that OPG-derived small molecules can be used as a probe to understand complex biological functions of RANK-TRANCE-OPG receptors and also can be use as a platform to develop more useful therapeutic agents for inflammation and bone disease.
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Osteoclast Differentiation Induced by Synthetic Octacalcium Phosphate Through Receptor Activator of NF-κB Ligand Expression in Osteoblasts
Masamichi Takami,Ayako Mochizuki,Atsushi Yamada,Keita Tachi,Baohong Zhao,Yoichi Miyamoto,Takahisa Anada,Yoshitomo Honda,Tomio Inoue,Masanori Nakamura,Osamu Suzuki,Ryutaro Kamijo +11 more
TL;DR: It is suggested that OCP itself decreases calcium levels around implanted OCP, which induces osteoclast differentiation through RANKL expression by osteoblasts, suggesting that soluble factors mediate osteOClast differentiation induced by OCP.
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Interleukin-4 inhibition of osteoclast differentiation is stronger than that of interleukin-13 and they are equivalent for induction of osteoprotegerin production from osteoblasts
Atsushi Yamada,Masamichi Takami,Tadaharu Kawawa,Rika Yasuhara,Baohong Zhao,Ayako Mochizuki,Yoichi Miyamoto,Tomoo Eto,Hisataka Yasuda,Yuko Nakamichi,Nacksung Kim,Takenobu Katagiri,Tatsuo Suda,Ryutaro Kamijo +13 more
TL;DR: The activities of IL‐4 and IL‐13 toward osteoclast precursors were shown to be different in regards to inhibition of osteOClast differentiation, whereas those toward osteoblasts for inducing OPG expression were equivalent.
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p38 Mitogen-activated protein kinase is crucially involved in osteoclast differentiation but not in cytokine production, phagocytosis, or dendritic cell differentiation of bone marrow macrophages.
Xiaotong Li,Nobuyuki Udagawa,Masamichi Takami,Nobuaki Sato,Nobuaki Sato,Yasuhiro Kobayashi,Naoyuki Takahashi +6 more
TL;DR: The role of p38 MAPK in the function and differentiation of mouse bone marrow macrophages and the differentiation of BMM phi into osteoclasts in response to receptor activator of nuclear factor-kappa B ligand or TNF alpha was strongly inhibited by SB203580.