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Imelda C. Hanson
Researcher at Baylor College of Medicine
Publications - 53
Citations - 1727
Imelda C. Hanson is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Severe combined immunodeficiency & Hematopoietic stem cell transplantation. The author has an hindex of 18, co-authored 53 publications receiving 1420 citations. Previous affiliations of Imelda C. Hanson include Boston Children's Hospital.
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Transplantation Outcomes for Severe Combined Immunodeficiency, 2000–2009
Sung-Yun Pai,Brent R. Logan,Linda M. Griffith,Rebecca H. Buckley,Roberta E. Parrott,Christopher C. Dvorak,Neena Kapoor,Imelda C. Hanson,Alexandra H. Filipovich,Soma Jyonouchi,Kathleen E. Sullivan,Trudy N. Small,Lauri Burroughs,Suzanne Skoda-Smith,Ann E. Haight,Audrey Grizzle,Michael A. Pulsipher,Ka Wah Chan,Ramsay Fuleihan,Elie Haddad,Brett Loechelt,Victor M. Aquino,Alfred P. Gillio,Jeffrey H. Davis,Alan P. Knutsen,Angela R. Smith,Theodore B. Moore,Marlis L. Schroeder,Frederick D. Goldman,James A. Connelly,Matthew H. Porteus,Qun Xiang,William T. Shearer,Thomas A. Fleisher,Donald B. Kohn,Jennifer M. Puck,Luigi D. Notarangelo,Morton J. Cowan,Richard J. O'Reilly +38 more
TL;DR: Transplants from donors other than matched siblings were associated with excellent survival among infants with SCID identified before the onset of infection.
Journal ArticleDOI
Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation
Katja G. Weinacht,Katja G. Weinacht,Louis-Marie Charbonnier,Fayhan Alroqi,Ashley S. Plant,Ashley S. Plant,Qi Qiao,Hao Wu,Clement Ma,Clement Ma,Troy R. Torgerson,Sergio D. Rosenzweig,Thomas A. Fleisher,Luigi D. Notarangelo,Imelda C. Hanson,Lisa R. Forbes,Talal A. Chatila +16 more
TL;DR: Janus kinase inhibitor therapy could represent an effective targeted treatment for long‐term disease control in severely affected patients for whom hematopoietic stem cell transplantation is not available.
Journal ArticleDOI
SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery
Elie Haddad,Brent R. Logan,Linda M. Griffith,Rebecca H. Buckley,Roberta E. Parrott,Susan E. Prockop,Trudy N. Small,Jessica Chaisson,Christopher C. Dvorak,Megan Murnane,Neena Kapoor,Hisham Abdel-Azim,Imelda C. Hanson,Caridad Martinez,Jack J. Bleesing,Sharat Chandra,Angela R. Smith,Matthew E. Cavanaugh,Soma Jyonouchi,Kathleen E. Sullivan,Lauri Burroughs,Lauri Burroughs,Suzanne Skoda-Smith,Ann E. Haight,Audrey G. Tumlin,Troy C. Quigg,Candace Taylor,Blachy J. Dávila Saldaña,Michael D. Keller,Christine M. Seroogy,Kenneth B. DeSantes,Aleksandra Petrovic,Jennifer W. Leiding,Jennifer W. Leiding,David C. Shyr,Hélène Decaluwe,Pierre Teira,Alfred P. Gillio,Alan P. Knutsen,Theodore B. Moore,Morris Kletzel,John Craddock,Victor M. Aquino,Jeffrey H. Davis,Lolie C. Yu,Geoffrey D.E. Cuvelier,Jeffrey J. Bednarski,Frederick D. Goldman,Elizabeth M. Kang,Evan Shereck,Matthew H. Porteus,James A. Connelly,Thomas A. Fleisher,Harry L. Malech,William T. Shearer,Paul Szabolcs,Monica S. Thakar,Mark Vander Lugt,Jennifer Heimall,Ziyan Yin,Michael A. Pulsipher,Sung-Yun Pai,Donald B. Kohn,Jennifer M. Puck,Morton J. Cowan,Richard J. O'Reilly,Luigi D. Notarangelo +66 more
TL;DR: A retrospective analysis of patients with severe combined immunodeficiency who received a hematopoietic cell transplantation as first-line treatment between 1982 and 2012 in 33 North American institutions found that Infection-free status and younger age at HCT were associated with improved survival.
Journal ArticleDOI
Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.
Melissa C. Mizesko,Melissa C. Mizesko,Pinaki P. Banerjee,Pinaki P. Banerjee,Linda Monaco-Shawver,Emily M. Mace,Emily M. Mace,William Bernal,Julie Sawalle-Belohradsky,Bernd H. Belohradsky,Valerie Heinz,Alexandra F. Freeman,Kathleen E. Sullivan,Steven M. Holland,Troy R. Torgerson,Waleed Al-Herz,Janet Chou,Imelda C. Hanson,Imelda C. Hanson,Michael H. Albert,Raif S. Geha,Ellen D. Renner,Jordan S. Orange,Jordan S. Orange +23 more
TL;DR: DOCK8 deficiency results in severely impaired NK cell function because of an inability to form a mature lytic immunologic synapse through targeted synaptic F-actin accumulation.
Journal ArticleDOI
Long-term outcomes of 176 patients with X-linked hyper-IgM syndrome treated with or without hematopoietic cell transplantation
M. Teresa de la Morena,David Leonard,Troy R. Torgerson,Otavio Cabral-Marques,Mary Slatter,Asghar Aghamohammadi,Sharat Chandra,Luis Murguia-Favela,Francisco A. Bonilla,Maria Kanariou,Rongras Damrongwatanasuk,Caroline Y. Kuo,Christopher C. Dvorak,Isabelle Meyts,Karin Chen,Lisa Kobrynski,Neena Kapoor,Darko Richter,Daniela DiGiovanni,Fatima Dhalla,Evangelia Farmaki,Carsten Speckmann,Teresa Espanol,Anna Shcherbina,Imelda C. Hanson,Jiri Litzman,John M. Routes,Melanie Wong,Ramsay Fuleihan,Suranjith L. Seneviratne,Trudy N. Small,Ales Janda,Liliana Bezrodnik,Reinhard Seger,Andrea C. Gómez Raccio,J. David M. Edgar,Janet Chou,Jordan K. Abbott,Joris M. van Montfrans,Luis Ignacio Gonzalez-Granado,Nancy Bunin,Necil Kutukculer,Paul Gray,Gisela Seminario,Srdjan Pasic,Victor M. Aquino,Christian A. Wysocki,Hassan Abolhassani,Morna J. Dorsey,Charlotte Cunningham-Rundles,Alan P. Knutsen,John W. Sleasman,Beatriz Tavares Costa Carvalho,Antonio Condino-Neto,Eyal Grunebaum,Helen Chapel,Hans D. Ochs,Alexandra H. Filipovich,M.J. Cowan,Andrew R. Gennery,Andrew J. Cant,Luigi D. Notarangelo,Chaim M. Roifman +62 more
TL;DR: No difference in survival was observed between patients treated with or without HCT across all diagnosis years (1964‐2013), however, survivors treated with HCT experienced somewhat greater well‐being, and hazards associated with H CT decreased, reaching levels of significantly less risk in the late 1990s.