Matthew E. Roth

TL;DR: A potent, nonsteroidal FXR ligand is used to show that FXR induces expression of small heterodimer partner 1 (SHP-1), an atypical member of the nuclear receptor family that lacks a DNA-binding domain that provides a molecular basis for the coordinate suppression of CYP7A1 and other genes involved in bile acid biosynthesis.

TL;DR: Mice heterozygous for the GATA3 mutation are fertile and appear in all respects to be normal, whereas homozygous mutant embryos die between days 11 and 12 postcoitum (p.c.) and display massive internal bleeding, marked growth retardation, severe deformities of the brain and spinal cord, and gross aberrations in fetal liver haematopoiesis.

TL;DR: It is reported that hypoxia specifically down-regulates the expression of RAD51, a key mediator of homologous recombination in mammalian cells, and a novel mechanism of genetic instability in the tumor microenvironment mediated by hypoxIA-induced suppression of the homologously recombination pathway in cancer cells is proposed.

TL;DR: In situ hybridization shows that mGATA-3 mRNA accumulation is temporally and spatially regulated during early development, and at least two regulatory elements appear to be required for appropriate tissue-restricted regulation after transfection of mGata-3-directed reporter genes into cells that naturally express GATA- 3 (T lymphocytes and neuroblastoma cells).

TL;DR: An mRNA profiling technique for determining differential gene expression that utilizes, but does not require, prior knowledge of gene sequences is described, which permits high-throughput reproducible detection of most expressed sequences with a sensitivity of greater than 1 part in 100,000.