M
Mauro S. G. Pavão
Researcher at Federal University of Rio de Janeiro
Publications - 84
Citations - 3703
Mauro S. G. Pavão is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Dermatan sulfate & Sulfation. The author has an hindex of 33, co-authored 81 publications receiving 3329 citations.
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Journal ArticleDOI
Glycosaminoglycans: key players in cancer cell biology and treatment
Nikos Afratis,Chrisostomi Gialeli,Dragana Nikitovic,Theodore Tsegenidis,Evgenia Karousou,Achilleas D. Theocharis,Mauro S. G. Pavão,George N. Tzanakakis,Nikos K. Karamanos +8 more
TL;DR: How the fine structural characteristics of glycosaminoglycans, and enzymes involved in their biosynthesis and degradation, are involved in cell signaling, cell function and cancer progression is summarized.
Journal ArticleDOI
Structure and Anticoagulant Activity of a Fucosylated Chondroitin Sulfate from Echinoderm SULFATED FUCOSE BRANCHES ON THE POLYSACCHARIDE ACCOUNT FOR ITS HIGH ANTICOAGULANT ACTION
Paulo A.S. Mourão,Mariana S. Pereira,Mauro S. G. Pavão,Barbara Mulloy,Douglas M. Tollefsen,Marie-Christine Mowinckel,Ulrich Abildgaard +6 more
TL;DR: Assays with purified reagents show that the fucosylated chondroitin sulfate can potentiate the thrombin inhibition activity of both antithrombin and heparin cofactor II.
Journal ArticleDOI
Selectin Blocking Activity of a Fucosylated Chondroitin Sulfate Glycosaminoglycan from Sea Cucumber EFFECT ON TUMOR METASTASIS AND NEUTROPHIL RECRUITMENT
Lubor Borsig,Lianchun Wang,Moisés C.M. Cavalcante,Larissa Cardilo-Reis,Paola L. Ferreira,Paulo A.S. Mourão,Jeffrey D. Esko,Mauro S. G. Pavão +7 more
TL;DR: In invertebrate FucCS may be a potential alternative to heparin for blocking metastasis and inflammatory reactions without the undesirable side effects of anticoagulant heparins.
Journal ArticleDOI
Highly Sulfated Dermatan Sulfates from Ascidians STRUCTURE VERSUS ANTICOAGULANT ACTIVITY OF THESE GLYCOSAMINOGLYCANS
Mauro S. G. Pavão,Karin R. M. Aiello,Claudio C. Werneck,L. C. F. Silva,Ana Paula Valente,Barbara Mulloy,Niall S. Colwell,Douglas M. Tollefsen,Paulo A.S. Mourão +8 more
TL;DR: These naturally oversulfated ascidian dermatan sulfates are sulfated at selected sites required for interaction with heparin cofactor II and thus have specific and potent anticoagulant activity.
Journal ArticleDOI
Extracellular galectin-3 in tumor progression and metastasis.
Anneliese Fortuna-Costa,Angélica Maciel Gomes,Eliene O. Kozlowski,Mariana P. Stelling,Mauro S. G. Pavão +4 more
TL;DR: Galectin-3 seems to play a relevant role in orchestrating distinct cell events in tumor microenvironment and for this reason, it can be considered a target in tumor therapies.