Melinda S. Merchant

TL;DR: An international panel of clinicians and laboratory-based scientists convened by Cancer Research UK identify and discuss seven challenges that must be overcome if the authors are to cure all patients with a brain tumour.

TL;DR: Surface plasmon resonance screening is used to identify compounds that bind EWS-FLI1 and might block its interaction with RHA, which provides proof of principle that inhibiting the interaction of mutant cancer-specific transcription factors with the normal cellular binding partners required for their oncogenic activity provides a promising strategy for the development of uniquely effective, tumor-specific anticancer agents.

TL;DR: The data suggest that robust, self-regenerating pools of CD8+ NY-ESO-1c259T cells produce a continuing supply of effector cells over several months that mediate clinically meaningful antitumor effects despite prolonged exposure to antigen.

TL;DR: Although no objective tumor regressions were observed with ipilimumab as a single agent, subjects with immune-related toxicities had an increased overall survival compared with those who showed no evidence of breaking tolerance.

TL;DR: The results indicate that IL-7Rα+ DCs are regulators of the peripheral CD4+ T cell niche and thatIL-7 signals in DCs prevent uncontrolled CD4- T cell population expansion in vivo.