M
Melissa Hanson
Researcher at National Institutes of Health
Publications - 16
Citations - 4836
Melissa Hanson is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Parkinson's disease & Parkinsonism. The author has an hindex of 13, co-authored 15 publications receiving 4522 citations. Previous affiliations of Melissa Hanson include Mayo Clinic.
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Journal ArticleDOI
α-Synuclein Locus Triplication Causes Parkinson's Disease
Andrew B. Singleton,Matthew J. Farrer,Joshua C. Johnson,Amanda Singleton,Stephen Hague,Jennifer M. Kachergus,Mary M. Hulihan,Terhi Peuralinna,Amalia Dutra,Robert L. Nussbaum,Sarah Lincoln,Anthony Crawley,Melissa Hanson,Demetrius M. Maraganore,Charles H. Adler,Mark R. Cookson,Manfred D. Muenter,Melisa J. Baptista,David Miller,J. Blancato,John Hardy,Katrina Gwinn-Hardy +21 more
TL;DR: In this article, the α-synuclein was identified as the major component of Lewy bodies, the pathological hallmark of Parkinson's disease, and of glial cell cytoplasmic inclusions.
Journal ArticleDOI
Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation
Stephen Hague,Ekaterina Rogaeva,Dena G. Hernandez,Cindy Gulick,Amanda Singleton,Melissa Hanson,Janel O. Johnson,Roberto Weiser,Marisol Gallardo,Bernard Ravina,Katrina Gwinn-Hardy,Anthony Crawley,Peter St George-Hyslop,Anthony E. Lang,Peter Heutink,Vincenzo Bonifati,Vincenzo Bonifati,John Hardy,Andrew B. Singleton +18 more
TL;DR: Observed sequence alterations in DJ‐1 are a rare cause of early‐onset PD, and one subject was diagnosed with probable PD at age 24 years with asymmetric onset and an excellent response to levodopa therapy.
Journal ArticleDOI
The structure of the tau haplotype in controls and in progressive supranuclear palsy
Alan M. Pittman,Amanda J. Myers,Jaime Duckworth,Leslie Bryden,Melissa Hanson,Patrick M. Abou-Sleiman,Nicholas W. Wood,John Hardy,John Hardy,Andrew J. Lees,Rohan de Silva +10 more
TL;DR: It is shown that the entire, fully extended H1 haplotype is associated with PSP, which implicates several other genes in addition to MAPT, as candidate pathogenic loci.
Journal ArticleDOI
Profile of families with Parkinsonism-predominant spinocerebellar ataxia type 2 (SCA2)
Sarah Furtado,Haydeh Payami,Haydeh Payami,Paul J. Lockhart,Melissa Hanson,John G. Nutt,Andrew Singleton,Amanda Singleton,Jamel Bower,Ryan J. Utti,Thomas D. Bird,Raúl de la Fuente-Fernández,Yoshio Tsuboi,Mary Lou Klimek,Oksana Suchowersky,John Hardy,Donald B. Calne,Zbigniew K. Wszolek,Matthew J. Farrer,Katrina Gwinn-Hardy,A. Jon Stoessl +20 more
TL;DR: The importance of testing for SCA2 in patients with parkinsonism and a family history of neurodegenerative disorders is emphasized, and testing forSCA2 is also important in studies of inherited parkinsonists.
Journal ArticleDOI
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies
Janel O. Johnson,Stephen Hague,Melissa Hanson,Alison M. Gibson,K. E. Wilson,E. W. Evans,Amanda Singleton,Aideen M. McInerney-Leo,Robert L. Nussbaum,Dena G. Hernandez,Marisol Gallardo,Ian G. McKeith,David J. Burn,M. Ryu,O. Hellström,Bernard Ravina,J. Eerola,Robert H. Perry,Evelyn Jaros,Pentti J. Tienari,Roberto Weiser,Katrina Gwinn-Hardy,Christopher Morris,John Hardy,AB Singleton +24 more
TL;DR: The authors assessed 101 familial PD probands, 325 sporadic PD cases, 65 patients with dementia with Lewy bodies, and 366 neurologically normal control subjects for SNCA multiplication and conclude this mutation is a rare cause of disease.