M
Merle Hirschmann
Researcher at Goethe University Frankfurt
Publications - 6
Citations - 82
Merle Hirschmann is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Photorhabdus & Xenorhabdus. The author has an hindex of 3, co-authored 4 publications receiving 34 citations.
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Journal ArticleDOI
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing
Edna Bode,Antje K. Heinrich,Merle Hirschmann,Desalegne Abebew,Yan-Ni Shi,Tien Duy Vo,Frank Wesche,Yi-Ming Shi,Peter Grün,Svenja Simonyi,Nadine Keller,Yvonne Engel,Sebastian L Wenski,Reuel Bennet,Sophie Beyer,Iris Bischoff,Anthony Buaya,Sophie C. Brandt,Ibrahim Cakmak,Harun Cimen,Simone Eckstein,Denia Frank,Robert Fürst,Martin Gand,Gerd Geisslinger,Selcuk Hazir,Marina Henke,Ralf Heermann,Virginie Lecaudey,Wilhelm Schäfer,Susanne Schiffmann,Anja Schüffler,Rebecca Schwenk,Marisa Skaljac,Eckhard Thines,Marco Thines,Thomas Ulshöfer,Andreas Vilcinskas,Thomas A. Wichelhaus,Helge B. Bode +39 more
TL;DR: This easyPACId approach (easy Promoter Activated Compound Identification) facilitates NP identification due to low interference from other NPs and allows direct bioactivity testing of supernatants containing secreted NPs, without laborious purification.
Journal ArticleDOI
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria
Yi-Ming Shi,Merle Hirschmann,Yan-Ni Shi,Shabbir Ahmed,Desalegne Abebew,Nicholas J. Tobias,Peter Grün,Jan J Crames,Laura Pöschel,Wolfgang Kuttenlochner,Christian Richter,Jennifer Herrmann,Rolf Müller,Aunchalee Thanwisai,Sacha J. Pidot,Timothy P. Stinear,Michael Groll,Yonggyun Kim,Helge B. Bode +18 more
TL;DR: In this paper , the pangenome and sequence similarity networks were used to identify 1,000 BGCs belonging to 176 families and identified the most conserved families are denoted by 11 BGC classes, which are eukaryotic proteasome inhibitors, virulence factors against insects, metallophores and insect immunosuppressants.
Journal ArticleDOI
Identification and occurrence of the hydroxamate siderophores aerobactin, putrebactin, avaroferrin and ochrobactin C as virulence factors from entomopathogenic bacteria.
TL;DR: Hydroxamate siderophore structures produced by entomopathogenic bacteria of the species Xenorhabdus and PhotorhabDus, which are known for their potential to produce bioactive natural products, are reported, required for their role as nematode symbiont and insect pathogen.
Journal ArticleDOI
LuxS-dependent AI-2 production is not involved in global regulation of natural product biosynthesis in Photorhabdus and Xenorhabdus
TL;DR: The role of another possible QS signal, autoinducer-2 (AI-2), in regulation of NP production is investigated and deleted luxS in three different entomopathogenic bacteria and compared NP levels in the mutant strains to the wild type but observed no difference to the WT strains.
Journal ArticleDOI
Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate‐Containing Natural Products in Diverse Bacteria
Yiming Shi,Jan J Crames,Laura Czech,Kenan A. J. Bozhüyük,Yan-Ni Shi,Merle Hirschmann,S. Lamberth,Peter Claus,Nicole Paczia,Christian Rückert,Jörn Kalinowski,Gert Bange,Helge B. Bode +12 more
TL;DR: The findings reveal the biosynthetic potential of a widespread benzobactin gene cluster and show a putative acyl AMP-ligase responsible for the last cyclization step of benzoxazolinate.