T
Thomas Ulshöfer
Researcher at Fraunhofer Society
Publications - 15
Citations - 221
Thomas Ulshöfer is an academic researcher from Fraunhofer Society. The author has contributed to research in topics: Downregulation and upregulation & Ceramide. The author has an hindex of 7, co-authored 15 publications receiving 132 citations.
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Journal ArticleDOI
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.
Max Eberle,Philipp Ebel,Christoph Mayer,Julia Barthelmes,Nadja Tafferner,Nerea Ferreirós,Thomas Ulshöfer,Marina Henke,Christian Foerch,Anika Männer de Bazo,Sabine Grösch,Gerd Geisslinger,Klaus Willecke,Susanne Schiffmann +13 more
TL;DR: It is concluded that CerS6/C16‐Cer mediates anti‐inflammatory effects during the development of EAE and MS possibly by suppressing the migration and deactivation of neutrophils.
Journal ArticleDOI
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis
Jennifer Kurz,Robert Brunkhorst,Christian Foerch,Leonard Blum,Marina Henke,Laureen Gabriel,Thomas Ulshöfer,Nerea Ferreirós,Michael J. Parnham,Gerd Geisslinger,Susanne Schiffmann +10 more
TL;DR: Investigation of Cers and their synthesizing/metabolizing enzymes in multiple sclerosis indicates that Cer metabolism is linked to G-CSF signaling in MS.
Journal ArticleDOI
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing
Edna Bode,Antje K. Heinrich,Merle Hirschmann,Desalegne Abebew,Yan-Ni Shi,Tien Duy Vo,Frank Wesche,Yi-Ming Shi,Peter Grün,Svenja Simonyi,Nadine Keller,Yvonne Engel,Sebastian L Wenski,Reuel Bennet,Sophie Beyer,Iris Bischoff,Anthony Buaya,Sophie C. Brandt,Ibrahim Cakmak,Harun Cimen,Simone Eckstein,Denia Frank,Robert Fürst,Martin Gand,Gerd Geisslinger,Selcuk Hazir,Marina Henke,Ralf Heermann,Virginie Lecaudey,Wilhelm Schäfer,Susanne Schiffmann,Anja Schüffler,Rebecca Schwenk,Marisa Skaljac,Eckhard Thines,Marco Thines,Thomas Ulshöfer,Andreas Vilcinskas,Thomas A. Wichelhaus,Helge B. Bode +39 more
TL;DR: This easyPACId approach (easy Promoter Activated Compound Identification) facilitates NP identification due to low interference from other NPs and allows direct bioactivity testing of supernatants containing secreted NPs, without laborious purification.
Journal ArticleDOI
Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach.
Rebecca Ingelfinger,Marina Henke,Luise Roser,Thomas Ulshöfer,Anjuli Calchera,Garima Singh,Michael J. Parnham,Gerd Geisslinger,Gerd Geisslinger,Robert Fürst,Imke Schmitt,Susanne Schiffmann +11 more
TL;DR: Overall, some of the lichen extracts tested in this study exhibit significant pharmacological activity in the context of inflammation and/or cancer, indicating that the group lichen-forming fungi includes promising members for further testing.
Journal ArticleDOI
Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy
Tivadar Feczkó,Albrecht Piiper,Saema Ansar,Frank W Blixt,Mukul Ashtikar,Susanne Schiffmann,Thomas Ulshöfer,Michael J. Parnham,Yifat Harel,Liron L. Israel,Jean-Paul Lellouche,Matthias G. Wacker,Matthias G. Wacker +12 more
TL;DR: In vivo evidence suggests that successful delivery of the neuropeptide is possible as well as the synergism between those two treatments, and the combination therapy of NGF and the small‐molecular MEK inhibitor U0126 showed a slight but not significant difference.