M
Marina Henke
Researcher at Fraunhofer Society
Publications - 21
Citations - 321
Marina Henke is an academic researcher from Fraunhofer Society. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 7, co-authored 14 publications receiving 214 citations.
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Journal ArticleDOI
Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation.
Christian Brenneis,Ovidiu Coste,Kai Altenrath,Carlo Angioni,Helmut Schmidt,Claus-Dieter Schuh,Dong Dong Zhang,Marina Henke,Andreas Weigert,Bernhard Brüne,Barry B. Rubin,Rolf M. Nüsing,Klaus Scholich,Gerd Geisslinger +13 more
TL;DR: Initial inflammation prepares the spinal cord for a negative feedback regulation by mPGES-1-derived PGE2 followed by EP2 activation, which limits the synthesis of inflammatory mediators during chronic inflammation.
Journal ArticleDOI
Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.
Julia Barthelmes,Anika Männer de Bazo,Yael Pewzner-Jung,Katja Schmitz,Christoph Mayer,Christian Foerch,Max Eberle,Nadja Tafferner,Nerea Ferreirós,Marina Henke,Gerd Geisslinger,Anthony H. Futerman,Sabine Grösch,Susanne Schiffmann +13 more
TL;DR: Data strongly indicate that G-CSF-induced CXCR2 expression is regulated in a CerS2-dependent manner and that CerS 2 thereby promotes the migration of neutrophils, thus, contributing to inflammation and the development of EAE and MS.
Journal ArticleDOI
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.
Max Eberle,Philipp Ebel,Christoph Mayer,Julia Barthelmes,Nadja Tafferner,Nerea Ferreirós,Thomas Ulshöfer,Marina Henke,Christian Foerch,Anika Männer de Bazo,Sabine Grösch,Gerd Geisslinger,Klaus Willecke,Susanne Schiffmann +13 more
TL;DR: It is concluded that CerS6/C16‐Cer mediates anti‐inflammatory effects during the development of EAE and MS possibly by suppressing the migration and deactivation of neutrophils.
Journal ArticleDOI
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis
Jennifer Kurz,Robert Brunkhorst,Christian Foerch,Leonard Blum,Marina Henke,Laureen Gabriel,Thomas Ulshöfer,Nerea Ferreirós,Michael J. Parnham,Gerd Geisslinger,Susanne Schiffmann +10 more
TL;DR: Investigation of Cers and their synthesizing/metabolizing enzymes in multiple sclerosis indicates that Cer metabolism is linked to G-CSF signaling in MS.
Journal ArticleDOI
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing
Edna Bode,Antje K. Heinrich,Merle Hirschmann,Desalegne Abebew,Yan-Ni Shi,Tien Duy Vo,Frank Wesche,Yi-Ming Shi,Peter Grün,Svenja Simonyi,Nadine Keller,Yvonne Engel,Sebastian L Wenski,Reuel Bennet,Sophie Beyer,Iris Bischoff,Anthony Buaya,Sophie C. Brandt,Ibrahim Cakmak,Harun Cimen,Simone Eckstein,Denia Frank,Robert Fürst,Martin Gand,Gerd Geisslinger,Selcuk Hazir,Marina Henke,Ralf Heermann,Virginie Lecaudey,Wilhelm Schäfer,Susanne Schiffmann,Anja Schüffler,Rebecca Schwenk,Marisa Skaljac,Eckhard Thines,Marco Thines,Thomas Ulshöfer,Andreas Vilcinskas,Thomas A. Wichelhaus,Helge B. Bode +39 more
TL;DR: This easyPACId approach (easy Promoter Activated Compound Identification) facilitates NP identification due to low interference from other NPs and allows direct bioactivity testing of supernatants containing secreted NPs, without laborious purification.