Michael A. Province

TL;DR: There is strong evidence of a QTL influencing HDL-cholesterol levels and a prominent candidate gene residing within the linkage region on 15q21 is hepatic lipase (HL), which has a major role in lipoprotein metabolism.

TL;DR: A random coefficient regression model was used to estimate growth parameters for the time series of observed serum glucose levels in the Replicate 1 of the Genetic Analysis Workshop 13 simulated data and showed more power to detect linkage to the major locus than either the cross-sectional or two-point slope approach; the RCR growth parameter showed a higher maximal LOD score for one of the minor loci.

TL;DR: The interaction between rs11774572 and CETP-TaqIB SNPs on HDL-C concentrations provides some insights into the underlying mechanisms of dyslipidemia that characterizes MetS.

TL;DR: The longevity‐enriched families in this study have a general health advantage spanning three generations together with indicators of family stability and only modest socioeconomic advantage implicate behavior as a key mechanism underlying familial aggregation of exceptional health and survival.

TL;DR: The reproducibility of the HERITAGE Family Study tests and assays considered in this paper was found to be very good, with no evidence of any systematic drift over time.