M
Michael A. Province
Researcher at Washington University in St. Louis
Publications - 409
Citations - 40871
Michael A. Province is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 79, co-authored 396 publications receiving 37334 citations. Previous affiliations of Michael A. Province include Jewish Hospital & Harvard University.
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Journal ArticleDOI
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Alisa K. Manning,Alisa K. Manning,Alisa K. Manning,Robert A. Scott,Jonna L. Grimsby,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Han Chen,Denis Rybin,Ching-Ti Liu,Lawrence F. Bielak,Inga Prokopenko,Najaf Amin,Daniel R. Barnes,Gemma Cadby,Gemma Cadby,Jouke-Jan Hottenga,Erik Ingelsson,Anne U. Jackson,Toby Johnson,Stavroula Kanoni,Claes Ladenvall,Vasiliki Lagou,Jari Lahti,Cécile Lecoeur,Cécile Lecoeur,Yongmei Liu,María Teresa Martínez-Larrad,May E. Montasser,Pau Navarro,John R. B. Perry,John R. B. Perry,John R. B. Perry,Laura J. Rasmussen-Torvik,Perttu Salo,Naveed Sattar,Dmitry Shungin,Dmitry Shungin,Rona J. Strawbridge,Toshiko Tanaka,Cornelia M. van Duijn,Ping An,Mariza de Andrade,Jeanette S. Andrews,Thor Aspelund,Mustafa Atalay,Yurii S. Aulchenko,Beverley Balkau,Stefania Bandinelli,Jacques S. Beckmann,John Beilby,Claire Bellis,Richard N. Bergman,John Blangero,Mladen Boban,Michael Boehnke,Eric Boerwinkle,Lori L. Bonnycastle,Dorret I. Boomsma,Ingrid B. Borecki,Yvonne Böttcher,Claude Bouchard,Eric J. Brunner,Danijela Budimir,Harry Campbell,Olga D. Carlson,Peter S. Chines,Robert Clarke,Francis S. Collins,Arturo Corbató-Anchuelo,David Couper,Ulf de Faire,George Dedoussis,Panos Deloukas,Maria Dimitriou,Josephine M. Egan,Gudny Eiriksdottir,Michael R. Erdos,Johan G. Eriksson,Elodie Eury,Elodie Eury,Luigi Ferrucci,Ian Ford,Nita G. Forouhi,Caroline S. Fox,Caroline S. Fox,Maria Grazia Franzosi,Paul W. Franks,Timothy M. Frayling,Philippe Froguel,Pilar Galan,Eco J. C. de Geus,Bruna Gigante,Nicole L. Glazer,Anuj Goel,Leif Groop,Vilmundur Gudnason,Göran Hallmans,Anders Hamsten,Ola Hansson,Tamara B. Harris,Caroline Hayward,Simon Heath,Serge Hercberg,Andrew A. Hicks,Aroon D. Hingorani,Albert Hofman,Jennie Hui,Joseph Hung,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Min A. Jhun,Paul C. D. Johnson,J. Wouter Jukema,Antti Jula,Wen Hong L. Kao,Jaakko Kaprio,Jaakko Kaprio,Sharon L.R. Kardia,Sirkka Keinänen-Kiukaanniemi,Mika Kivimäki,Ivana Kolcic,Peter Kovacs,Meena Kumari,Johanna Kuusisto,Kirsten Ohm Kyvik,Markku Laakso,Timo A. Lakka,Lars Lannfelt,G. Mark Lathrop,Lenore J. Launer,Karin Leander,Guo Li,Lars Lind,Jaana Lindström,Stéphane Lobbens,Stéphane Lobbens,Ruth J. F. Loos,Jian'an Luan,Valeriya Lyssenko,Reedik Mägi,Reedik Mägi,Patrik K. E. Magnusson,Michael Marmot,Pierre Meneton,Karen L. Mohlke,Vincent Mooser,Mario A. Morken,Iva Miljkovic,Narisu Narisu,Jeffrey R. O'Connell,Ken K. Ong,Ben A. Oostra,Lyle J. Palmer,Lyle J. Palmer,Aarno Palotie,Aarno Palotie,Aarno Palotie,James S. Pankow,John F. Peden,Nancy L. Pedersen,Marina Pehlić,Leena Peltonen,Leena Peltonen,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Marijana Peričić,Markus Perola,Louis Pérusse,Patricia A. Peyser,Ozren Polasek,Peter P. Pramstaller,Michael A. Province,Katri Räikkönen,Rainer Rauramaa,Emil Rehnberg,Kenneth Rice,Jerome I. Rotter,Igor Rudan,Igor Rudan,Aimo Ruokonen,Timo Saaristo,Maria Sabater-Lleal,Veikko Salomaa,David B. Savage,Richa Saxena,Richa Saxena,Peter Schwarz,Udo Seedorf,Bengt Sennblad,Manuel Serrano-Ríos,Alan R. Shuldiner,Eric J.G. Sijbrands,David S. Siscovick,Johannes H. Smit,Kerrin S. Small,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Albert V. Smith,Alena Stančáková,Kathleen Stirrups,Michael Stumvoll,Yan V. Sun,Amy J. Swift,Anke Tönjes,Jaakko Tuomilehto,Stella Trompet,André G. Uitterlinden,Matti Uusitupa,Max Vikström,Veronique Vitart,Marie-Claude Vohl,Benjamin F. Voight,Peter Vollenweider,Gerard Waeber,Dawn M. Waterworth,Hugh Watkins,Hugh Watkins,Eleanor Wheeler,Elisabeth Widen,Sarah H. Wild,Sara M. Willems,Gonneke Willemsen,James F. Wilson,Jacqueline C.M. Witteman,Alan F. Wright,Hanieh Yaghootkar,Diana Zelenika,Tatijana Zemunik,Lina Zgaga,Lina Zgaga,Nicholas J. Wareham,Mark I. McCarthy,Inês Barroso,Inês Barroso,Richard M. Watanabe,Jose C. Florez,Jose C. Florez,José Dupuis,José Dupuis,James B. Meigs,Claudia Langenberg +243 more
TL;DR: Six previously unknown loci associated with fasting insulin at P < 5 × 10−8 in combined discovery and follow-up analyses of 52 studies comprising up to 96,496 non-diabetic individuals are presented.
Journal ArticleDOI
New loci associated with kidney function and chronic kidney disease
Anna Köttgen,Anna Köttgen,Cristian Pattaro,Carsten A. Böger,Christian Fuchsberger,Matthias Olden,Nicole L. Glazer,Afshin Parsa,Xiaoyi Gao,Qiong Yang,Albert V. Smith,Jeffrey R. O'Connel,Man Li,Helena Schmidt,Toshiko Tanaka,Toshiko Tanaka,Aaron Isaacs,Shamika Ketkar,Shih-Jen Hwang,Andrew D. Johnson,Abbas Dehghan,Alexander Teumer,Guillaume Paré,Elizabeth J. Atkinson,Tanja Zeller,Kurt Lohman,Marilyn C. Cornelis,Nicole Probst-Hensch,Nicole Probst-Hensch,Florian Kronenberg,Anke Tönjes,Caroline Hayward,Thor Aspelund,Gudny Eiriksdottir,Lenore J. Launer,Tamara B. Harris,Evadnie Rampersaud,Braxton D. Mitchel,Dan E. Arking,Eric Boerwinkle,Maksim Struchalin,Margherita Cavalieri,Andrew B. Singleton,Francesco Giallauria,Jeffrey Metter,Ian H. de Boer,Talin Haritunians,Thomas Lumley,David S. Siscovick,Bruce M. Psaty,M. CarolaZillikens,Ben A. Oostra,Mary F. Feitosa,Michael A. Province,Mariza de Andrade,Stephen T. Turner,Arne Schillert,Andreas Ziegler,Philipp S. Wild,Renate B. Schnabel,Sandra Wilde,Thomas Münzel,Tennille S. Leak,Thomas Illig,Norman Klopp,Christa Meisinger,H.-Erich Wichmann,Wolfgang Koenig,Lina Zgaga,Tatijana Zemunik,Ivana Kolcic,Cosetta Minelli,Frank B. Hu,Åsa Johansson,Wilmar Igl,Ghazal Zaboli,Sarah H. Wild,Alan F. Wright,Harry Campbell,David Ellinghaus,Stefan Schreiber,Yurii S. Aulchenko,Janine F. Felix,Fernando Rivadeneira,André G. Uitterlinden,Albert Hofman,Medea Imboden,Medea Imboden,Dorothea Nitsch,Anita Brandstätter,Barbara Kollerits,Lyudmyla Kedenko,Reedik Mägi,Michael Stumvoll,Peter Kovacs,Mladen Boban,Susan Campbell,Karlhans Endlich,Henry Völzke,Heyo K. Kroemer,Matthias Nauck,Uwe Völker,Ozren Polasek,Veronique Vitart,Sunita Badola,Alex Parker,Paul M. Ridker,Sharon L.R. Kardia,Stefan Blankenberg,Yongmei Liu,Gary C. Curhan,Andre Franke,Thierry Rochat,Bernhard Paulweber,Inga Prokopenko,Wei Wang,Wei Wang,Vilmundur Gudnason,Alan R. Shuldine,Josef Coresh,Reinhold E. Schmidt,Luigi Ferrucci,Michael G. Shlipak,Cornelia M. van Duijn,Ingrid B. Borecki,Bernhard K. Krämer,Igor Rudan,Ulf Gyllensten,James F. Wilson,Jacqueline C. M. Witteman,Peter P. Pramstaller,Rainer Rettig,Nicholas D. Hastie,Daniel I. Chasman,Wen Hong L. Kao,Iris M. Heid,Caroline S. Fox,Caroline S. Fox +137 more
TL;DR: The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry to identify new susceptibility loci for reduced renal function as estimated by serum creatinine, serum cystatin c and CKD.
Journal ArticleDOI
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Robert A. Scott,Vasiliki Lagou,Ryan P. Welch,Eleanor Wheeler,May E. Montasser,Jian'an Luan,Reedik Mägi,Rona J. Strawbridge,Emil Rehnberg,Stefan Gustafsson,Stavroula Kanoni,Laura J. Rasmussen-Torvik,Loic Yengo,Cécile Lecoeur,Dmitry Shungin,Serena Sanna,Carlo Sidore,Paul C. D. Johnson,J. Wouter Jukema,Toby Johnson,Anubha Mahajan,Niek Verweij,Gudmar Thorleifsson,Jouke-Jan Hottenga,Sonia Shah,Albert V. Smith,Bengt Sennblad,Christian Gieger,Perttu Salo,Markus Perola,Nicholas J. Timpson,David M. Evans,Beate St Pourcain,Ying Wu,Jeanette S. Andrews,Jennie Hui,Lawrence F. Bielak,Wei Zhao,Momoko Horikoshi,Pau Navarro,Aaron Isaacs,Jeffrey R. O'Connell,Kathleen Stirrups,Veronique Vitart,Caroline Hayward,Tõnu Esko,Evelin Mihailov,Ross M. Fraser,Tove Fall,Benjamin F. Voight,Soumya Raychaudhuri,Han Chen,Cecilia M. Lindgren,Andrew P. Morris,Nigel W. Rayner,Neil Robertson,Denis Rybin,Ching-Ti Liu,Jacques S. Beckmann,Sara M. Willems,Peter S. Chines,Anne U. Jackson,Hyun Min Kang,Heather M. Stringham,Kijoung Song,Toshiko Tanaka,John F. Peden,Anuj Goel,Andrew A. Hicks,Ping An,Martina Müller-Nurasyid,Anders Franco-Cereceda,Lasse Folkersen,Letizia Marullo,Hanneke Jansen,Albertine J. Oldehinkel,Marcel Bruinenberg,James S. Pankow,Kari E. North,Nita G. Forouhi,Ruth J. F. Loos,Sarah Edkins,Tibor V. Varga,Göran Hallmans,Heikki Oksa,Mulas Antonella,Ramaiah Nagaraja,Stella Trompet,Ian Ford,Stephan J. L. Bakker,Augustine Kong,Meena Kumari,Bruna Gigante,Christian Herder,Patricia B. Munroe,Mark J. Caulfield,Jula Antti,Massimo Mangino,Kerrin S. Small,Iva Miljkovic,Yongmei Liu,Mustafa Atalay,Wieland Kiess,Alan James,Fernando Rivadeneira,André G. Uitterlinden,Colin N. A. Palmer,Alex S. F. Doney,Gonneke Willemsen,Johannes H. Smit,Susan Campbell,Ozren Polasek,Lori L. Bonnycastle,Serge Hercberg,Maria Dimitriou,Jennifer L. Bolton,Gerard R Fowkes,Peter Kovacs,Jaana Lindström,Tatijana Zemunik,Stefania Bandinelli,Sarah H. Wild,Hanneke Basart,Wolfgang Rathmann,Harald Grallert,Winfried Maerz,Marcus E. Kleber,Bernhard O. Boehm,Annette Peters,Peter P. Pramstaller,Michael A. Province,Ingrid B. Borecki,Nicholas D. Hastie,Igor Rudan,Harry Campbell,Hugh Watkins,Martin Farrall,Michael Stumvoll,Luigi Ferrucci,Dawn M. Waterworth,Richard N. Bergman,Francis S. Collins,Jaakko Tuomilehto,Richard M. Watanabe,Eco J. C. de Geus,Brenda W.J.H. Penninx,Albert Hofman,Ben A. Oostra,Bruce M. Psaty,Peter Vollenweider,James F. Wilson,Alan F. Wright,G. Kees Hovingh,Andres Metspalu,Matti Uusitupa,Patrik K. E. Magnusson,Kirsten Ohm Kyvik,Jaakko Kaprio,Jackie F. Price,George Dedoussis,Panos Deloukas,Pierre Meneton,Lars Lind,Michael Boehnke,Alan R. Shuldiner,Cornelia M. van Duijn,Andrew D. Morris,Anke Toenjes,Patricia A. Peyser,John Beilby,John Beilby,Antje Körner,Johanna Kuusisto,Markku Laakso,Stefan R. Bornstein,Peter Schwarz,Timo A. Lakka,Rainer Rauramaa,Linda S. Adair,George Davey Smith,Tim D. Spector,Thomas Illig,Ulf de Faire,Anders Hamsten,Vilmundur Gudnason,Mika Kivimäki,Aroon D. Hingorani,Sirkka Keinänen-Kiukaanniemi,T. Saaristo,Dorret I. Boomsma,Kari Stefansson,Pim van der Harst,Josée Dupuis,Nancy L. Pedersen,Naveed Sattar,Tamara B. Harris,Francesco Cucca,Samuli Ripatti,Veikko Salomaa,Karen L. Mohlke,Beverley Balkau,Philippe Froguel,Anneli Pouta,Marjo-Riitta Järvelin,Nicholas J. Wareham,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Mark I. McCarthy,Paul W. Franks,James B. Meigs,Tanya M. Teslovich,Jose C. Florez,Claudia Langenberg,Erik Ingelsson,Inga Prokopenko,Inês Barroso +216 more
TL;DR: Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations and further functional analysis of these newly discovered loci will further improve the understanding of glycemic control.
Journal ArticleDOI
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Sonja I. Berndt,Stefan Gustafsson,Stefan Gustafsson,Reedik Mägi,Reedik Mägi,Andrea Ganna,Eleanor Wheeler,Mary F. Feitosa,Anne E. Justice,Keri L. Monda,Keri L. Monda,Damien C. Croteau-Chonka,Felix R. Day,Tõnu Esko,Tove Fall,Teresa Ferreira,Davide Gentilini,Anne U. Jackson,Jian'an Luan,Joshua C. Randall,Joshua C. Randall,Sailaja Vedantam,Sailaja Vedantam,Sailaja Vedantam,Cristen J. Willer,Thomas W. Winkler,Andrew R. Wood,Tsegaselassie Workalemahu,Tsegaselassie Workalemahu,Yi-Juan Hu,Sang Hong Lee,Liming Liang,Danyu Lin,Josine L. Min,Benjamin M. Neale,Gudmar Thorleifsson,Jian Yang,Jian Yang,Eva Albrecht,Najaf Amin,Jennifer L. Bragg-Gresham,Gemma Cadby,Gemma Cadby,Martin den Heijer,Niina Eklund,Krista Fischer,Anuj Goel,Jouke-Jan Hottenga,Jennifer E. Huffman,Ivonne Jarick,Åsa Johansson,Åsa Johansson,Toby Johnson,Stavroula Kanoni,Marcus E. Kleber,Inke R. König,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Claudia Lamina,Cécile Lecoeur,Cécile Lecoeur,Guo Li,Massimo Mangino,Wendy L. McArdle,Carolina Medina-Gomez,Martina Müller-Nurasyid,Julius S. Ngwa,Ilja M. Nolte,Lavinia Paternoster,Sonali Pechlivanis,Markus Perola,Markus Perola,Markus Perola,Marjolein J. Peters,Michael Preuss,Lynda M. Rose,Jianxin Shi,Dmitry Shungin,Dmitry Shungin,Albert V. Smith,Rona J. Strawbridge,Ida Surakka,Ida Surakka,Alexander Teumer,Mieke D. Trip,Jonathan Tyrer,Jana V. van Vliet-Ostaptchouk,Liesbeth Vandenput,Lindsay L. Waite,Jing Hua Zhao,Devin Absher,Folkert W. Asselbergs,Mustafa Atalay,Antony P. Attwood,Anthony J. Balmforth,Hanneke Basart,John Beilby,Lori L. Bonnycastle,Paolo Brambilla,Marcel Bruinenberg,Harry Campbell,Daniel I. Chasman,Daniel I. Chasman,Peter S. Chines,Francis S. Collins,John M. C. Connell,John M. C. Connell,William O.C.M. Cookson,Ulf de Faire,Femmie de Vegt,Mariano Dei,Maria Dimitriou,Sarah Edkins,Karol Estrada,David M. Evans,Martin Farrall,Marco M Ferrario,Jean Ferrières,Lude Franke,Francesca Frau,Pablo V. Gejman,Pablo V. Gejman,Harald Grallert,Henrik Grönberg,Vilmundur Gudnason,Alistair S. Hall,Per Hall,Anna-Liisa Hartikainen,Caroline Hayward,Nancy L. Heard-Costa,Andrew C. Heath,Johannes Hebebrand,Georg Homuth,Frank B. Hu,Sarah E. Hunt,Elina Hyppönen,Carlos Iribarren,Kevin B. Jacobs,Kevin B. Jacobs,John-Olov Jansson,Antti Jula,Mika Kähönen,Sekar Kathiresan,Frank Kee,Kay-Tee Khaw,Mika Kivimäki,Wolfgang Koenig,Aldi T. Kraja,Meena Kumari,Kari Kuulasmaa,Johanna Kuusisto,Jaana Laitinen,Timo A. Lakka,Claudia Langenberg,Claudia Langenberg,Lenore J. Launer,Lars Lind,Jaana Lindström,Jianjun Liu,Antonio Liuzzi,Marja-Liisa Lokki,Mattias Lorentzon,Pamela A. F. Madden,Patrik K. E. Magnusson,Paolo Manunta,Diana Marek,Diana Marek,Winfried März,Winfried März,Irene Mateo Leach,Barbara McKnight,Sarah E. Medland,Evelin Mihailov,Lili Milani,Grant W. Montgomery,Vincent Mooser,Thomas W. Mühleisen,Patricia B. Munroe,Arthur W. Musk,Arthur W. Musk,Narisu Narisu,Gerjan Navis,George Nicholson,Ellen A. Nohr,Ken K. Ong,Ben A. Oostra,Ben A. Oostra,Colin N. A. Palmer,Aarno Palotie,Aarno Palotie,John F. Peden,Nancy L. Pedersen,Annette Peters,Ozren Polasek,Anneli Pouta,Anneli Pouta,Peter P. Pramstaller,Inga Prokopenko,Inga Prokopenko,Carolin Pütter,Aparna Radhakrishnan,Aparna Radhakrishnan,Aparna Radhakrishnan,Olli T. Raitakari,Olli T. Raitakari,Augusto Rendon,Fernando Rivadeneira,Igor Rudan,Timo Saaristo,Jennifer G. Sambrook,Jennifer G. Sambrook,Alan R. Sanders,Alan R. Sanders,Serena Sanna,Jouko Saramies,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,So-Youn Shin,Stefano Signorini,Juha Sinisalo,Boris Skrobek,Boris Skrobek,Nicole Soranzo,Nicole Soranzo,Alena Stančáková,Klaus Stark,Jonathan Stephens,Jonathan Stephens,Kathleen Stirrups,Ronald P. Stolk,Michael Stumvoll,Amy J. Swift,Eirini V. Theodoraki,Barbara Thorand,David-Alexandre Trégouët,Elena Tremoli,Melanie M. van der Klauw,Joyce B. J. van Meurs,Sita H. Vermeulen,Jorma Viikari,Jarmo Virtamo,Veronique Vitart,Gérard Waeber,Zhaoming Wang,Zhaoming Wang,Elisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Bernhard R. Winkelmann,Jacqueline C.M. Witteman,Bruce H. R. Wolffenbuttel,Andrew Wong,Alan F. Wright,M. Carola Zillikens,Philippe Amouyel,Bernhard O. Boehm,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,L. Adrienne Cupples,Daniele Cusi,George Dedoussis,Jeanette Erdmann,Jeanette Erdmann,Johan G. Eriksson,Johan G. Eriksson,Johan G. Eriksson,Paul W. Franks,Paul W. Franks,Paul W. Franks,Philippe Froguel,Philippe Froguel,Philippe Froguel,Christian Gieger,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Christian Hengstenberg,Andrew A. Hicks,Aroon D. Hingorani,Anke Hinney,Albert Hofman,Kees Hovingh,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Sirkka Keinänen-Kiukaanniemi,Sirkka Keinänen-Kiukaanniemi,Lambertus A. Kiemeney,Diana Kuh,Markku Laakso,Terho Lehtimäki,Douglas F. Levinson,Nicholas G. Martin,Andres Metspalu,Andrew D. Morris,Markku S. Nieminen,Inger Njølstad,Claes Ohlsson,Albertine J. Oldehinkel,Willem H. Ouwehand,Lyle J. Palmer,Brenda W.J.H. Penninx,Chris Power,Michael A. Province,Bruce M. Psaty,Lu Qi,Lu Qi,Rainer Rauramaa,Paul M. Ridker,Paul M. Ridker,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Harold Snieder,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Kari Stefansson,Anke Tönjes,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Pim van der Harst,Peter Vollenweider,Henri Wallaschofski,Nicholas J. Wareham,Hugh Watkins,H-Erich Wichmann,James F. Wilson,Gonçalo R. Abecasis,Themistocles L. Assimes,Inês Barroso,Inês Barroso,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Timothy M. Frayling,Leif Groop,Talin Haritunian,Iris M. Heid,David J. Hunter,David J. Hunter,Robert C. Kaplan,Fredrik Karpe,Fredrik Karpe,Miriam F. Moffatt,Karen L. Mohlke,Jeffrey R. O'Connell,Yudi Pawitan,Eric E. Schadt,David Schlessinger,Valgerdur Steinthorsdottir,David P. Strachan,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Cornelia M. van Duijn,Peter M. Visscher,Anna Maria Di Blasio,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Cecilia M. Lindgren,Andrew P. Morris,David Meyre,David Meyre,David Meyre,André Scherag,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Elizabeth K. Speliotes,Kari E. North,Ruth J. F. Loos,Erik Ingelsson +385 more
TL;DR: A genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry finds a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
Journal ArticleDOI
Genetic Structure, Self-Identified Race/Ethnicity, and Confounding in Case-Control Association Studies
Hua Tang,Thomas Quertermous,Beatriz L. Rodriguez,Sharon L.R. Kardia,Xiaofeng Zhu,Andrew Brown,James S. Pankow,Michael A. Province,Steven C. Hunt,Eric Boerwinkle,Nicholas J. Schork,Neil Risch,Neil Risch +12 more
TL;DR: Ancient geographic ancestry, which is highly correlated with self-identified race/ethnicity--as opposed to current residence--is the major determinant of genetic structure in the U.S. population.