Michael A. Province

TL;DR: Findings similar to data that the 9p21 locus was not associated with risk of major adverse events in >2400 white patients, with a trend toward a protective effect are observed.

TL;DR: In this article , associations of single nucleotide polymorphisms (SNPs) of the MLXIPL lipid gene with Alzheimer's (AD) and coronary heart disease (CHD) and potentially causal mediation effects of their risk factors, high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG), were examined in two samples of European ancestry from the US (22,712 individuals 587/2,608 AD/CHD cases) and the UK Biobank (UKB) (232,341 individuals; 809/15,269 AD/ChD cases).

TL;DR: In this article , the authors test whether the protective effect of familial longevity persists after age 100 using more restrictive definitions of long-lived families, and the results showed that longlived siblings presented better overall survival after age100 than sporadic long-livers (HR=0.80 95%CI= 0.71-0.91).

TL;DR: High PUFA intakes were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146, and significant interactions were due exclusively to (n-6) PUFA intake.

TL;DR: The problems, pitfalls, and challenges of this exciting effort to map genes for atherosclerosis, heart disease, and their major risk factors using whole genome linkage and/or disequilibrium scans are examined and illustrated with lessons from an earlier mapping problem.