Michael A. Province

TL;DR: PPARA IVS7 2498 genotype is associated with heterogeneity in 1-year outcome in response to BB among patients following ACS, and may predict which patients benefit from BB therapy, putatively related to the effect of myocardial PPARalpha expression on beta-adrenergic responsiveness.

TL;DR: Sequencing analysis of family-based associations for age-related phenotypes can identify rare or novel variants, and a novel variant significantly associated with exceptional survival in the 3’ UTR OBFC1 is found.

TL;DR: Using in vitro analyses, it is shown that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity.

TL;DR: This model provides an objective method of investigating developmental changes in the correlational structure of families over time using repeated‐measures and of estimating continuous changes in familiality with age.

TL;DR: Dogs with intermediate TPMT activity receiving azathioprine had significantly lower neutrophil counts during week 4 than during weeks 0-3, whereas those with high activity did not have a significant change in neutrophils count, suggesting that T PMT activity, as measured in RBCs, is not the sole cause of severe azATHioprine-associated myelosuppression in dogs.