M
Michael A. Province
Researcher at Washington University in St. Louis
Publications - 409
Citations - 40871
Michael A. Province is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 79, co-authored 396 publications receiving 37334 citations. Previous affiliations of Michael A. Province include Jewish Hospital & Harvard University.
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Journal ArticleDOI
An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program.
Aldi T. Kraja,D. C. Rao,Alan B. Weder,Thomas H. Mosley,Stephen T. Turner,Chao A. Hsiung,Thomas Quertermous,Richard S. Cooper,J. David Curb,Michael A. Province +9 more
TL;DR: Ascertaining for hypertension or T2D increased the MetS prevalence in networks compared with the one in the US general population, and obesity was the most prominent risk factor contributing to both c- metS and q-MetS.
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Vascular filtration function in galactose-fed versus diabetic rats: the role of polyol pathway activity.
Giuseppe Pugliese,Ronald G. Tilton,Amanda Speedy,Katherine Chang,Michael A. Province,Charles Kilo,Joseph R. Williamson +6 more
TL;DR: The hypothesis that increased metabolism of glucose via the sorbitol pathway is of central importance in mediating virtually all of the early changes in vascular filtration function associated with diabetes in the kidney, as well as in the eyes, nerves, and aorta is supported.
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Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan
Alexander M. Kulminski,Konstantin G. Arbeev,Irina Culminskaya,Liubov Arbeeva,Svetlana V. Ukraintseva,Eric Stallard,Kaare Christensen,Nicole Schupf,Michael A. Province,Anatoli I. Yashin +9 more
TL;DR: The results suggest a pivotal role of non-sex-specific cancer as a nonlinear modulator of survival in this sample that increases the risk of death of the ApoE4 carriers by 150% compared to the non-carriers.
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Tree-based recursive partitioning methods for subdividing sibpairs into relatively more homogeneous subgroups.
TL;DR: Simulation studies found that partitioning sibpairs into homogeneous subgroups is feasible and significantly increases the power to detect linkage, thus demonstrating the practical utility and potential this new methodology holds.
Journal ArticleDOI
A genetic marker at the glucokinase gene locus for type 2 (non-insulin-dependent) diabetes mellitus in Mauritian Creoles.
Ken C. Chiu,Michael A. Province,G. K. Dowse,Paul Zimmet,G. Wagner,S. W. Serjeantson,M. A. Permutt +6 more
TL;DR: The data suggest that the Z+2 allele is an important risk factor for Type 2 diabetes in Mauritian Creoles, but not in Mauritians Indians, and imply that the glucokinase gene may play a role in the pathogenesis of Type 2abetes in MauritIAN Creoles.