Michael B. Drennan

TL;DR: The structure and function of a novel class of aromatic α‐galactosylceramide structurally related glycolipids with marked Th1 bias in both mice and men are reported, leading to superior tumour protection in vivo.

TL;DR: The role of the gut microbiota in shaping local and systemic immune responses and how disturbances in the host–microorganism interplay can potentially affect the development and progression of rheumatic diseases are reviewed.

TL;DR: It is demonstrated that neonatal colonization of gut microbiota influences generalized autoimmunity in adult life, and antinuclear antibody production is influenced by the presence of commensal gut flora, in particular increased colonization with segmented filamentous bacteria, and IL‐17 receptor signaling.

TL;DR: Calprotectin measurements in stool and serum, in addition to CRP, may provide a promising strategy to identify patients with SpA at risk of bowel inflammation and could play a role in overall patient stratification.

TL;DR: Comparison analysis compared the current gold standard methods - clinical scoring and histological examination - with alternative methods based on scoring of X-ray or micro-computed tomography images and investigated the significance of systemically expressed proteins, involved in CIA pathogenesis, that have potential as biomarkers.