R
Ryan Schlimgen
Researcher at National Institutes of Health
Publications - 10
Citations - 1752
Ryan Schlimgen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Monocyte & Fludarabine. The author has an hindex of 10, co-authored 10 publications receiving 1603 citations. Previous affiliations of Ryan Schlimgen include Duke University & Tufts University.
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Journal ArticleDOI
Germline mutations in the extracellular domains of the 55 kda tnf receptor, tnfr1, define a family of dominantly inherited autoinflammatory syndromes
Michael F. McDermott,Ivona Aksentijevich,Jérôme Galon,Elizabeth M. McDermott,B. William Ogunkolade,Michael Centola,Elizabeth Mansfield,Massimo Gadina,Leena Karenko,Tom Pettersson,John McCarthy,David M. Frucht,Martin Aringer,Yelizaveta Torosyan,Anna-Maija Teppo,Meredith Wilson,H.Mehmet Karaarslan,Ying Wan,Ian Todd,Geryl Wood,Ryan Schlimgen,Thisum R. Kumarajeewa,Sheldon M. Cooper,John P. Vella,Christopher I. Amos,John C. Mulley,Kathleen A. Quane,Michael G. Molloy,Annamari Ranki,Richard J. Powell,Graham A. Hitman,John J. O'Shea,Daniel L. Kastner +32 more
TL;DR: It is proposed that the autoinflammatory phenotype results from impaired downregulation of membrane TNFR1 and diminished shedding of potentially antagonistic soluble receptor inTNFR1-associated periodic syndromes.
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IL-10 improves skin disease and modulates endothelial activation and leukocyte effector function in patients with psoriatic arthritis.
Iain B. McInnes,Gabor G. Illei,Carol L. Danning,Cheryl Yarboro,Marianne Crane,Takashi Kuroiwa,Ryan Schlimgen,Eric Lee,Barbara Foster,Donald Flemming,Calman Prussin,Thomas A. Fleisher,Dimitrios T. Boumpas +12 more
TL;DR: It is demonstrated that a short course of IL-10 modulates immune responses in vivo via diverse effects on endothelial activation, and leukocyte recruitment and effector function, and such biological changes may result in clinically meaningful improvement in disease activity.
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Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus.
TL;DR: A current view of cis‐acting mechanisms that enforce the TCRα/δ locus developmental program is provided, and the unresolved issues that command the attention of the laboratories are emphasized.
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Distinct T Cell/Renal Tubular Epithelial Cell Interactions Define Differential Chemokine Production: Implications for Tubulointerstitial Injury in Chronic Glomerulonephritides
TL;DR: Activation of renal tubular cells by infiltrating T cells can amplify and perpetuate local inflammatory responses through chemokine production differentially mediated by soluble and cell contact-dependent factors.
Journal ArticleDOI
Risks Associated With Lentiviral Vector Exposures and Prevention Strategies
Ryan Schlimgen,John Howard,Dawn P. Wooley,Maureen Thompson,Lindsey R. Baden,Otto O. Yang,David C. Christiani,Gustavo Mostoslavsky,David V. Diamond,Elizabeth Gilman Duane,Karen Byers,Thomas Winters,Jeffrey A. Gelfand,Gary Fujimoto,T. Warner Hudson,Jatin M. Vyas +15 more
TL;DR: A framework is provided for principal investigators, Institutional Biosafety Committees, and occupational health professionals to assess and communicate the risks of exposure to staff and for federal research and regulatory agencies for tracking LVV exposures to evaluate long-term outcomes.