M
Michael Chang
Researcher at Stanford University
Publications - 80
Citations - 4436
Michael Chang is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Telomere. The author has an hindex of 20, co-authored 57 publications receiving 4107 citations. Previous affiliations of Michael Chang include Emory University & University of California, Irvine.
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Journal ArticleDOI
Global Mapping of the Yeast Genetic Interaction Network
Amy Hin Yan Tong,Guillaume Lesage,Gary D. Bader,Huiming Ding,Hong Xu,Xiaofeng Xin,James D. Young,Gabriel F. Berriz,Renee L. Brost,Michael Chang,Yiqun Chen,Xin Cheng,Gordon Chua,Helena Friesen,Debra S. Goldberg,Jennifer Haynes,Christine Humphries,Grace He,Shamiza Hussein,Lizhu Ke,Nevan J. Krogan,Zhijian Li,Joshua N. Levinson,Hong Lu,Patrice Menard,Christella Munyana,Ainslie B. Parsons,Owen Ryan,Raffi Tonikian,Tania Michelle Roberts,Anne-Marie Sdicu,Jesse Shapiro,Bilal N. Sheikh,Bernhard Suter,Sharyl L. Wong,Lan V. Zhang,Hongwei Zhu,Christopher G. Burd,Sean Munro,Chris Sander,Jasper Rine,Jack Greenblatt,Matthias Peter,Anthony Bretscher,Graham Bell,Frederick P. Roth,Grant W. Brown,Brenda J. Andrews,Howard Bussey,Charles Boone +49 more
TL;DR: Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.
Journal ArticleDOI
A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.
TL;DR: A systematic screen of the set of viable Saccharomyces cerevisiae haploid gene deletion mutants is performed and 103 genes whose deletion causes sensitivity to the DNA-damaging agent methyl methanesulfonate are identified, including a subset of genes that show a specific MMS response.
Journal ArticleDOI
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates
Leonard Wu,Csanád Z. Bachrati,Jiongwen Ou,Chang Xu,Jinhu Yin,Michael Chang,Weidong Wang,Lei Li,Grant W. Brown,Ian D. Hickson +9 more
TL;DR: It is shown that a recently identified third component of the human BLM/hTOPO IIIalpha complex, BLAP75/RMI1, promotes dissolution catalyzed by hTOPOIIIalpha, and evidence that BLAP 75/R MI1 acts by recruiting hTOPo IIIalpha to double Holliday junctions is presented.
Journal ArticleDOI
Identification of Protein Complexes Required for Efficient Sister Chromatid Cohesion
Melanie L. Mayer,Isabelle Pot,Michael Chang,Hong Xu,Victoria Aneliunas,Teresa Kwok,Rick Newitt,Ruedi Aebersold,Charles Boone,Grant W. Brown,Philip Hieter +10 more
TL;DR: The data indicate that synthetic genetic array analysis coupled with specific secondary screens can effectively identify protein complexes functionally related to a reference gene and find that genes involved in mitotic spindle integrity and positioning have a previously unrecognized role in sister chromatid cohesion.
Journal ArticleDOI
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex
Michael Chang,Mohammed Bellaoui,Chaoying Zhang,Ridhdhi Desai,Pavel Morozov,Lissette Delgado-Cruzata,Rodney Rothstein,Greg A. Freyer,Charles Boone,Grant W. Brown +9 more
TL;DR: The authors showed that the genetic interaction profile of the gene RMI1 (RecQ-mediated genome instability), also known as NCE4 and YPL024W, was highly similar to that of SGS1 and TOP3, suggesting a functional relationship between Rmi1 and the Sgs1/Top3 complex.